TY - JOUR
T1 - Temporal course of depressive symptoms during the development of Alzheimer disease
AU - Wilson, R. S.
AU - Hoganson, G. M.
AU - Rajan, Kumar
AU - Barnes, L. L.
AU - Mendes De Leon, C. F.
AU - Evans, D. A.
PY - 2010/7/6
Y1 - 2010/7/6
N2 - Objective: To characterize change in depressive symptoms before and after the onset of dementia in Alzheimer disease (AD). Method: We used data from the Chicago Health and Aging Project, a longitudinal cohort study of risk factors for AD in a geographically defined population of old people. Two subsets were analyzed. In 357 individuals who developed incident AD during the study, self-report of depressive symptoms (Center for Epidemiologic Studies Depression Scale) was obtained at 3-year intervals for a mean of 8 to 9 years. In 340 individuals who agreed to annual data collection, informant report of depressive symptoms (Hamilton Depression Rating Scale) was obtained for a mean of 3 years after a diagnosis of AD (n = 107), mild cognitive impairment (n = 81), or no cognitive impairment (n = 152). Results: The incident AD group reported a barely perceptible increase in depressive symptoms during 6 to 7 years of observation before the diagnosis (0.04 symptoms per year) and no change during 2 to 3 years of observation after the diagnosis except for a slight decrease in positive affect. In those with annual follow-up, neither AD nor its precursor, mild cognitive impairment, was associated with change in informant report of depressive symptoms during a mean of 3 years of observation. Conclusion: Depressive symptoms show little change during the development and progression of AD to a moderate level of dementia severity.
AB - Objective: To characterize change in depressive symptoms before and after the onset of dementia in Alzheimer disease (AD). Method: We used data from the Chicago Health and Aging Project, a longitudinal cohort study of risk factors for AD in a geographically defined population of old people. Two subsets were analyzed. In 357 individuals who developed incident AD during the study, self-report of depressive symptoms (Center for Epidemiologic Studies Depression Scale) was obtained at 3-year intervals for a mean of 8 to 9 years. In 340 individuals who agreed to annual data collection, informant report of depressive symptoms (Hamilton Depression Rating Scale) was obtained for a mean of 3 years after a diagnosis of AD (n = 107), mild cognitive impairment (n = 81), or no cognitive impairment (n = 152). Results: The incident AD group reported a barely perceptible increase in depressive symptoms during 6 to 7 years of observation before the diagnosis (0.04 symptoms per year) and no change during 2 to 3 years of observation after the diagnosis except for a slight decrease in positive affect. In those with annual follow-up, neither AD nor its precursor, mild cognitive impairment, was associated with change in informant report of depressive symptoms during a mean of 3 years of observation. Conclusion: Depressive symptoms show little change during the development and progression of AD to a moderate level of dementia severity.
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UR - http://www.scopus.com/inward/citedby.url?scp=77954637784&partnerID=8YFLogxK
U2 - 10.1212/WNL.0b013e3181e620c5
DO - 10.1212/WNL.0b013e3181e620c5
M3 - Article
C2 - 20603481
AN - SCOPUS:77954637784
VL - 75
SP - 21
EP - 26
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 1
ER -