Abstract
Objective: To characterize change in depressive symptoms before and after the onset of dementia in Alzheimer disease (AD). Method: We used data from the Chicago Health and Aging Project, a longitudinal cohort study of risk factors for AD in a geographically defined population of old people. Two subsets were analyzed. In 357 individuals who developed incident AD during the study, self-report of depressive symptoms (Center for Epidemiologic Studies Depression Scale) was obtained at 3-year intervals for a mean of 8 to 9 years. In 340 individuals who agreed to annual data collection, informant report of depressive symptoms (Hamilton Depression Rating Scale) was obtained for a mean of 3 years after a diagnosis of AD (n = 107), mild cognitive impairment (n = 81), or no cognitive impairment (n = 152). Results: The incident AD group reported a barely perceptible increase in depressive symptoms during 6 to 7 years of observation before the diagnosis (0.04 symptoms per year) and no change during 2 to 3 years of observation after the diagnosis except for a slight decrease in positive affect. In those with annual follow-up, neither AD nor its precursor, mild cognitive impairment, was associated with change in informant report of depressive symptoms during a mean of 3 years of observation. Conclusion: Depressive symptoms show little change during the development and progression of AD to a moderate level of dementia severity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 21-26 |
| Number of pages | 6 |
| Journal | Neurology |
| Volume | 75 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jul 6 2010 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Clinical Neurology
Cite this
Temporal course of depressive symptoms during the development of Alzheimer disease. / Wilson, R. S.; Hoganson, G. M.; Rajan, Kumar; Barnes, L. L.; Mendes De Leon, C. F.; Evans, D. A.
In: Neurology, Vol. 75, No. 1, 06.07.2010, p. 21-26.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Temporal course of depressive symptoms during the development of Alzheimer disease
AU - Wilson, R. S.
AU - Hoganson, G. M.
AU - Rajan, Kumar
AU - Barnes, L. L.
AU - Mendes De Leon, C. F.
AU - Evans, D. A.
PY - 2010/7/6
Y1 - 2010/7/6
N2 - Objective: To characterize change in depressive symptoms before and after the onset of dementia in Alzheimer disease (AD). Method: We used data from the Chicago Health and Aging Project, a longitudinal cohort study of risk factors for AD in a geographically defined population of old people. Two subsets were analyzed. In 357 individuals who developed incident AD during the study, self-report of depressive symptoms (Center for Epidemiologic Studies Depression Scale) was obtained at 3-year intervals for a mean of 8 to 9 years. In 340 individuals who agreed to annual data collection, informant report of depressive symptoms (Hamilton Depression Rating Scale) was obtained for a mean of 3 years after a diagnosis of AD (n = 107), mild cognitive impairment (n = 81), or no cognitive impairment (n = 152). Results: The incident AD group reported a barely perceptible increase in depressive symptoms during 6 to 7 years of observation before the diagnosis (0.04 symptoms per year) and no change during 2 to 3 years of observation after the diagnosis except for a slight decrease in positive affect. In those with annual follow-up, neither AD nor its precursor, mild cognitive impairment, was associated with change in informant report of depressive symptoms during a mean of 3 years of observation. Conclusion: Depressive symptoms show little change during the development and progression of AD to a moderate level of dementia severity.
AB - Objective: To characterize change in depressive symptoms before and after the onset of dementia in Alzheimer disease (AD). Method: We used data from the Chicago Health and Aging Project, a longitudinal cohort study of risk factors for AD in a geographically defined population of old people. Two subsets were analyzed. In 357 individuals who developed incident AD during the study, self-report of depressive symptoms (Center for Epidemiologic Studies Depression Scale) was obtained at 3-year intervals for a mean of 8 to 9 years. In 340 individuals who agreed to annual data collection, informant report of depressive symptoms (Hamilton Depression Rating Scale) was obtained for a mean of 3 years after a diagnosis of AD (n = 107), mild cognitive impairment (n = 81), or no cognitive impairment (n = 152). Results: The incident AD group reported a barely perceptible increase in depressive symptoms during 6 to 7 years of observation before the diagnosis (0.04 symptoms per year) and no change during 2 to 3 years of observation after the diagnosis except for a slight decrease in positive affect. In those with annual follow-up, neither AD nor its precursor, mild cognitive impairment, was associated with change in informant report of depressive symptoms during a mean of 3 years of observation. Conclusion: Depressive symptoms show little change during the development and progression of AD to a moderate level of dementia severity.
UR - http://www.scopus.com/inward/record.url?scp=77954637784&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954637784&partnerID=8YFLogxK
U2 - 10.1212/WNL.0b013e3181e620c5
DO - 10.1212/WNL.0b013e3181e620c5
M3 - Article
VL - 75
SP - 21
EP - 26
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 1
ER -