Temporal and spatial rearrangements of a repetitive element array on C57BL/6J mouse genome

Kang Hoon Lee, Lisa Yee, Debora Lim, David G Greenhalgh, Kiho Cho

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Repetitive elements (REs) make up the vast majority of the mammalian genomes. We identified species-specific genomic libraries of RE arrays. The non-random configurations of RE arrays suggest their functions. We tested whether RE arrays undergo age- and tissue/cell-specific rearrangements. An RE array of C57BL/6J mice, containing tandem repeats of a mosaic of transposable REs, was selected to examine rearrangements in different ages and tissues. There were marked changes in the array configuration in the genomes of the skin and brain in all mice of six weeks and older, whereas the heart and liver had alterations at 29. weeks. The temporal variations were confirmed by identifying putative rearrangement junctions. Temporal and spatial rearrangements of certain RE arrays may contribute to the acquired characteristics of the genome information system.

Original languageEnglish (US)
Pages (from-to)439-445
Number of pages7
JournalExperimental and Molecular Pathology
Volume98
Issue number3
DOIs
StatePublished - Jun 1 2015

Keywords

  • Acquired genome characteristics
  • Dynamic genome
  • Four-dimensional genome unit
  • RE array<inf>CHR7.32</inf>
  • Spatial rearrangement
  • Temporal rearrangement

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Biology
  • Pathology and Forensic Medicine

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