Temporal and Geographic Clustering of Polyomavirus-Associated Olfactory Tumors in 10 Free-Ranging Raccoons (Procyon lotor)

F. Giannitti, Robert Higgins, Patricia Pesavento, F. Dela Cruz, D. L. Clifford, M. Piazza, A. Parker Struckhoff, L. Del Valle, A. W. Bollen, Birgit Puschner, E. Kerr, H. Gelberg, Asli Mete, S. McGraw, Leslie Woods

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Reports of primary nervous system tumors in wild raccoons are extremely rare. Olfactory tumors were diagnosed postmortem in 9 free-ranging raccoons from 4 contiguous counties in California and 1 raccoon from Oregon within a 26-month period between 2010 and 2012. We describe the geographic and temporal features of these 10 cases, including the laboratory diagnostic investigations and the neuropathologic, immunohistochemical, and ultrastructural characteristics of these tumors in the affected animals. All 9 raccoons from California were found within a localized geographic region of the San Francisco Bay Area (within a 44.13-km radius). The tight temporal and geographic clustering and consistent anatomic location in the olfactory system of tumor types not previously described in raccoons (malignant peripheral nerve sheath tumors and undifferentiated sarcomas) strongly suggest either a common cause or a precipitating factor leading to induction or potentiation of neuro-oncogenesis and so prompted an extensive diagnostic investigation to explore possible oncogenic infectious and/or toxic causes. By a consensus polymerase chain reaction strategy, a novel, recently reported polyomavirus called raccoon polyomavirus was identified in all 10 tumors but not in the normal brain tissue from the affected animals, suggesting that the virus might play a role in neuro-oncogenesis. In addition, expression of the viral protein T antigen was detected in all tumors containing the viral sequences. We discuss the potential role of raccoon polyomavirus as an oncogenic virus.

Original languageEnglish (US)
Pages (from-to)832-845
Number of pages14
JournalVeterinary Pathology
Volume51
Issue number4
DOIs
StatePublished - Jul 1 2014

Fingerprint

Raccoons
Polyomavirus
Procyon lotor
Cluster Analysis
neoplasms
Neoplasms
carcinogenesis
Carcinogenesis
oncogenic viruses
Nervous System Neoplasms
Precipitating Factors
Oncogenic Viruses
San Francisco
peripheral nerves
Poisons
viral proteins
Viral Tumor Antigens
Neurilemmoma
sarcoma
Viral Proteins

Keywords

  • cancer cluster
  • malignant peripheral nerve sheath tumor
  • olfactory nerve
  • Procyon lotor
  • raccoon polyomavirus
  • sarcoma
  • secondary brain tumor
  • wildlife

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Temporal and Geographic Clustering of Polyomavirus-Associated Olfactory Tumors in 10 Free-Ranging Raccoons (Procyon lotor). / Giannitti, F.; Higgins, Robert; Pesavento, Patricia; Cruz, F. Dela; Clifford, D. L.; Piazza, M.; Struckhoff, A. Parker; Valle, L. Del; Bollen, A. W.; Puschner, Birgit; Kerr, E.; Gelberg, H.; Mete, Asli; McGraw, S.; Woods, Leslie.

In: Veterinary Pathology, Vol. 51, No. 4, 01.07.2014, p. 832-845.

Research output: Contribution to journalArticle

Giannitti, F. ; Higgins, Robert ; Pesavento, Patricia ; Cruz, F. Dela ; Clifford, D. L. ; Piazza, M. ; Struckhoff, A. Parker ; Valle, L. Del ; Bollen, A. W. ; Puschner, Birgit ; Kerr, E. ; Gelberg, H. ; Mete, Asli ; McGraw, S. ; Woods, Leslie. / Temporal and Geographic Clustering of Polyomavirus-Associated Olfactory Tumors in 10 Free-Ranging Raccoons (Procyon lotor). In: Veterinary Pathology. 2014 ; Vol. 51, No. 4. pp. 832-845.
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