Temporal and anatomic relationship between virus replication and cytokine gene expression after vaginal simian immunodeficiency virus infection

Kristina Abel, David M Rocke, Barinderpal Chohan, Linda Fritts, Chris J Miller

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102 Citations (Scopus)

Abstract

The current knowledge about early innate immune responses at mucosal sites of human immunodeficiency vires (HIV) entry is limited but likely to be important in the design of effective HIV vaccines against heterosexual transmission. This study examined the temporal and anatomic relationship between vires replication, lymphocyte depletion, and cytokine gene expression levels in mucosal and lymphoid tissues in a vaginal-transmission model of HIV in rhesus macaques. The results of the study show that the kinetics of cytokine gene expression levels in the acute phase of infection are positively correlated with virus replication in a tissue. Thus, cytokine responses after vaginal simian immunodeficiency virus (SIV) inoculation are earliest and strongest in mucosal tissues of the genital tract and lowest in systemic lymphoid tissues. Importantly, the early cytokine response was dominated by the induction of proinflaminatory cytokines, while the induction of cytokines with antiviral activity, alpha/beta interferon, occurred too late to prevent virus replication and dissemination. Thus, the early cytokine response favors immune activation, resulting in the recruitment of potential target cells for SIV. Further, unique cytokine gene expression patterns were observed in distinct anatomic locations with a rapid and persistent inflammatory response in the gut tbat is consistent with the gut being the major site of early CD4 T-cell depletion in SIV infection.

Original languageEnglish (US)
Pages (from-to)12164-12172
Number of pages9
JournalJournal of Virology
Volume79
Issue number19
DOIs
StatePublished - Oct 2005

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Simian immunodeficiency virus
Simian Immunodeficiency Virus
Virus Diseases
Virus Replication
virus replication
cytokines
Cytokines
Gene Expression
gene expression
infection
immunosuppression
Lymphoid Tissue
Mucous Membrane
digestive system
Lymphocyte Depletion
interferon-beta
Interferon-beta
Heterosexuality
Macaca mulatta
Innate Immunity

ASJC Scopus subject areas

  • Immunology

Cite this

Temporal and anatomic relationship between virus replication and cytokine gene expression after vaginal simian immunodeficiency virus infection. / Abel, Kristina; Rocke, David M; Chohan, Barinderpal; Fritts, Linda; Miller, Chris J.

In: Journal of Virology, Vol. 79, No. 19, 10.2005, p. 12164-12172.

Research output: Contribution to journalArticle

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