Templated virus deposition: From molecular-scale force measurements to kinetic Monte Carlo simulations

S. Elhadj, R. Friddle, G. Gilmer, Aleksandr Noy, J. J. De Yoreo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The use of macromolecular scaffolds for hierarchical organization of molecules and materials is a common strategy in living systems that leads to emergent behavior. Here we describe an effort to relate interaction force measurements between viruses and modified substrates to the energy landscape during virus assembly on surfaces. Potentials and binding energies are then used in kinetic Monte Carlo simulations to predict assembly morphology under controlled conditions replicated experimentally. We use atomic force microscope (AFM) tips functionalized with specific chemical species to measure interactions in the assembly system, which includes Cow Pea Mosaic Virus (CPMV). CPMV virus particles were engineered to express specific functional groups to modulate the strength and kinetics of interactions and assembly morphology. We show that the CPMV morphological evolution predicted by the simulations correlates with AFM observations.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Pages499-500
Number of pages2
Volume1
StatePublished - 2008
Externally publishedYes
Event2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008 - Quebec City, QC, United States
Duration: Jun 1 2008Jun 5 2008

Other

Other2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008
CountryUnited States
CityQuebec City, QC
Period6/1/086/5/08

Keywords

  • Assembly
  • Energy
  • Force
  • Monte carlo
  • Virus

ASJC Scopus subject areas

  • Mechanical Engineering

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  • Cite this

    Elhadj, S., Friddle, R., Gilmer, G., Noy, A., & De Yoreo, J. J. (2008). Templated virus deposition: From molecular-scale force measurements to kinetic Monte Carlo simulations. In Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008 (Vol. 1, pp. 499-500)