Templated virus deposition: From molecular-scale force measurements to kinetic Monte Carlo simulations

S. Elhadj; R. Friddle; G. Gilmer; Aleksandr Noy; J. J. De Yoreo

Templated virus deposition: From molecular-scale force measurements to kinetic Monte Carlo simulations

S. Elhadj, R. Friddle, G. Gilmer, Aleksandr Noy, J. J. De Yoreo

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The use of macromolecular scaffolds for hierarchical organization of molecules and materials is a common strategy in living systems that leads to emergent behavior. Here we describe an effort to relate interaction force measurements between viruses and modified substrates to the energy landscape during virus assembly on surfaces. Potentials and binding energies are then used in kinetic Monte Carlo simulations to predict assembly morphology under controlled conditions replicated experimentally. We use atomic force microscope (AFM) tips functionalized with specific chemical species to measure interactions in the assembly system, which includes Cow Pea Mosaic Virus (CPMV). CPMV virus particles were engineered to express specific functional groups to modulate the strength and kinetics of interactions and assembly morphology. We show that the CPMV morphological evolution predicted by the simulations correlates with AFM observations.

Original language	English (US)
Title of host publication	Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Pages	499-500
Number of pages	2
Volume	1
State	Published - 2008
Externally published	Yes
Event	2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008 - Quebec City, QC, United States Duration: Jun 1 2008 → Jun 5 2008

Other

Other	2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008
Country/Territory	United States
City	Quebec City, QC
Period	6/1/08 → 6/5/08

Keywords

Assembly
Energy
Force
Monte carlo
Virus

ASJC Scopus subject areas

Mechanical Engineering

Cite this

Templated virus deposition : From molecular-scale force measurements to kinetic Monte Carlo simulations. / Elhadj, S.; Friddle, R.; Gilmer, G.; Noy, Aleksandr; De Yoreo, J. J.

Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. Vol. 1 2008. p. 499-500.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Elhadj, S, Friddle, R, Gilmer, G, Noy, A & De Yoreo, JJ 2008, Templated virus deposition: From molecular-scale force measurements to kinetic Monte Carlo simulations. in Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. vol. 1, pp. 499-500, 2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008, Quebec City, QC, United States, 6/1/08.

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Templated virus deposition: From molecular-scale force measurements to kinetic Monte Carlo simulations

Abstract

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Keywords

ASJC Scopus subject areas

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