Temperature feedback and collagen cross-linking in argon laser vascular welding

W. Small IV, P. M. Celliers, G. E. Kopchok, K. M. Reiser, N. J. Heredia, D. J. Maitland, D. C. Eder, R. A. London, M. Heilbron, F. Hussain, R. A. White, L. B. Da Silva, Dennis L Matthews

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

A preliminary single-animal study of in vivo argon laser vascular welding was conducted using a canine model. The effects of temperature feedback control and saline drip cooling on patency and collagen cross-linking were investigated. The surface temperature at the centre of the laser spot was monitored using a two-colour infrared thermometer. The surface temperature was limited by either a saline drip or feedback control of the laser. Acute patency was evaluated and collagen cross-link assays were performed. Though both protocols yielded successful tissue fusion, welds maintained at a surface temperature of 50°C using feedback control had an elevated cross-link count compared to controls, whereas tissues irradiated without feedback control experienced a cross-link decrease. Simulations using the LATIS (LAser-TISsue) computer code suggest that drip-cooled procedures achieve significantly higher temperatures beneath the tissue surface than temperature feedback-controlled procedures. Differences between the volumetric heating associated with drip-cooled and feedback-controlled protocols may account for the different effects on collagen cross-links. Covalent mechanisms may play a role in argon laser vascular fusion.

Original languageEnglish (US)
Pages (from-to)98-105
Number of pages8
JournalLasers in Medical Science
Volume13
Issue number2
DOIs
StatePublished - 1998
Externally publishedYes

Keywords

  • Collagen
  • Infrared thermometry
  • Radiometry
  • Temperature
  • Tissue fusion

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Surgery

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