Techniques to improve the spatial sampling of micropet-a high resolution animal pet tomograph

A. Chatziioannou, R. W. Silverman, K. Meadors, T. H. Farquhar, Simon R Cherry

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A method is described to improve the spatial sampling of microPET, a high resolution PET scanner designed for imaging small laboratory animals. The high intrinsic resolution of the microPET detector (1.58 mm FWHM), in combination with the stationary ring geometry of the tomograph, generate an imaging system which is inherently spatially undersampled. As a result the imaging resolution measured with a three-dimensional (3-D) filtered backprojection (FBP) algorithm for a point source at the center of the field of view (CFOV) is only 1.8 mm FWHM and has large fluctuations at positions near the CFOV. A small wobble motion was introduced via a circular motion of the scanner bed in the transverse plane, with a wobble radius of 300 fj,m. The data was acquired with a step-and-shoot method by dividing the wobble circle into a number of equidistantly sampled intervals. The separate sinograms were interpolated to a finely resampled sinogram, which was reconstructed with the 3-D filtered backprojection algorithm. The resulting images demonstrated full recovery of the intrinsic detector resolution and elimination of the local nonuniformities of the point spread function (PSF) at the CFOV, with three wobble samples. The resulting average resolution improvement for the central 5 cm of the FOV was approximately 13% in the radial and 19% in the tangential direction, with an associated 50% penalty in the reconstructed image noise. Index Terms-Image reconstruction, positron emission tomography, small animal imaging, spatial sampling.

Original languageEnglish (US)
Pages (from-to)422-427
Number of pages6
JournalIEEE Transactions on Nuclear Science
Volume47
Issue number2 PART 2
StatePublished - 2000

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field of view
animals
Animals
sampling
Sampling
Full width at half maximum
Imaging techniques
scanners
high resolution
Detectors
Positron emission tomography
detectors
Optical transfer function
point spread functions
image reconstruction
Image reconstruction
penalties
nonuniformity
Imaging systems
point sources

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Nuclear Energy and Engineering

Cite this

Chatziioannou, A., Silverman, R. W., Meadors, K., Farquhar, T. H., & Cherry, S. R. (2000). Techniques to improve the spatial sampling of micropet-a high resolution animal pet tomograph. IEEE Transactions on Nuclear Science, 47(2 PART 2), 422-427.

Techniques to improve the spatial sampling of micropet-a high resolution animal pet tomograph. / Chatziioannou, A.; Silverman, R. W.; Meadors, K.; Farquhar, T. H.; Cherry, Simon R.

In: IEEE Transactions on Nuclear Science, Vol. 47, No. 2 PART 2, 2000, p. 422-427.

Research output: Contribution to journalArticle

Chatziioannou, A, Silverman, RW, Meadors, K, Farquhar, TH & Cherry, SR 2000, 'Techniques to improve the spatial sampling of micropet-a high resolution animal pet tomograph', IEEE Transactions on Nuclear Science, vol. 47, no. 2 PART 2, pp. 422-427.
Chatziioannou, A. ; Silverman, R. W. ; Meadors, K. ; Farquhar, T. H. ; Cherry, Simon R. / Techniques to improve the spatial sampling of micropet-a high resolution animal pet tomograph. In: IEEE Transactions on Nuclear Science. 2000 ; Vol. 47, No. 2 PART 2. pp. 422-427.
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