Abstract
A method is described to improve the spatial sampling of microPET, a high resolution PET scanner designed for imaging small laboratory animals. The high intrinsic resolution of the microPET detector (1.58 mm FWHM), in combination with the stationary ring geometry of the tomograph, generate an imaging system which is inherently spatially undersampled. As a result the imaging resolution measured with a three-dimensional (3-D) filtered backprojection (FBP) algorithm for a point source at the center of the field of view (CFOV) is only 1.8 mm FWHM and has large fluctuations at positions near the CFOV. A small wobble motion was introduced via a circular motion of the scanner bed in the transverse plane, with a wobble radius of 300 fj,m. The data was acquired with a step-and-shoot method by dividing the wobble circle into a number of equidistantly sampled intervals. The separate sinograms were interpolated to a finely resampled sinogram, which was reconstructed with the 3-D filtered backprojection algorithm. The resulting images demonstrated full recovery of the intrinsic detector resolution and elimination of the local nonuniformities of the point spread function (PSF) at the CFOV, with three wobble samples. The resulting average resolution improvement for the central 5 cm of the FOV was approximately 13% in the radial and 19% in the tangential direction, with an associated 50% penalty in the reconstructed image noise. Index Terms-Image reconstruction, positron emission tomography, small animal imaging, spatial sampling.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 422-427 |
| Number of pages | 6 |
| Journal | IEEE Transactions on Nuclear Science |
| Volume | 47 |
| Issue number | 2 PART 2 |
| State | Published - 2000 |
Fingerprint
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Nuclear Energy and Engineering
Cite this
Techniques to improve the spatial sampling of micropet-a high resolution animal pet tomograph. / Chatziioannou, A.; Silverman, R. W.; Meadors, K.; Farquhar, T. H.; Cherry, Simon R.
In: IEEE Transactions on Nuclear Science, Vol. 47, No. 2 PART 2, 2000, p. 422-427.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Techniques to improve the spatial sampling of micropet-a high resolution animal pet tomograph
AU - Chatziioannou, A.
AU - Silverman, R. W.
AU - Meadors, K.
AU - Farquhar, T. H.
AU - Cherry, Simon R
PY - 2000
Y1 - 2000
N2 - A method is described to improve the spatial sampling of microPET, a high resolution PET scanner designed for imaging small laboratory animals. The high intrinsic resolution of the microPET detector (1.58 mm FWHM), in combination with the stationary ring geometry of the tomograph, generate an imaging system which is inherently spatially undersampled. As a result the imaging resolution measured with a three-dimensional (3-D) filtered backprojection (FBP) algorithm for a point source at the center of the field of view (CFOV) is only 1.8 mm FWHM and has large fluctuations at positions near the CFOV. A small wobble motion was introduced via a circular motion of the scanner bed in the transverse plane, with a wobble radius of 300 fj,m. The data was acquired with a step-and-shoot method by dividing the wobble circle into a number of equidistantly sampled intervals. The separate sinograms were interpolated to a finely resampled sinogram, which was reconstructed with the 3-D filtered backprojection algorithm. The resulting images demonstrated full recovery of the intrinsic detector resolution and elimination of the local nonuniformities of the point spread function (PSF) at the CFOV, with three wobble samples. The resulting average resolution improvement for the central 5 cm of the FOV was approximately 13% in the radial and 19% in the tangential direction, with an associated 50% penalty in the reconstructed image noise. Index Terms-Image reconstruction, positron emission tomography, small animal imaging, spatial sampling.
AB - A method is described to improve the spatial sampling of microPET, a high resolution PET scanner designed for imaging small laboratory animals. The high intrinsic resolution of the microPET detector (1.58 mm FWHM), in combination with the stationary ring geometry of the tomograph, generate an imaging system which is inherently spatially undersampled. As a result the imaging resolution measured with a three-dimensional (3-D) filtered backprojection (FBP) algorithm for a point source at the center of the field of view (CFOV) is only 1.8 mm FWHM and has large fluctuations at positions near the CFOV. A small wobble motion was introduced via a circular motion of the scanner bed in the transverse plane, with a wobble radius of 300 fj,m. The data was acquired with a step-and-shoot method by dividing the wobble circle into a number of equidistantly sampled intervals. The separate sinograms were interpolated to a finely resampled sinogram, which was reconstructed with the 3-D filtered backprojection algorithm. The resulting images demonstrated full recovery of the intrinsic detector resolution and elimination of the local nonuniformities of the point spread function (PSF) at the CFOV, with three wobble samples. The resulting average resolution improvement for the central 5 cm of the FOV was approximately 13% in the radial and 19% in the tangential direction, with an associated 50% penalty in the reconstructed image noise. Index Terms-Image reconstruction, positron emission tomography, small animal imaging, spatial sampling.
UR - http://www.scopus.com/inward/record.url?scp=0033704969&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033704969&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0033704969
VL - 47
SP - 422
EP - 427
JO - IEEE Transactions on Nuclear Science
JF - IEEE Transactions on Nuclear Science
SN - 0018-9499
IS - 2 PART 2
ER -