Abstract
The preparation of technetium-99m aminopolycarboxylate complexes was carried out under anerobic conditions using stannous ions as the reducing agent. Electrophoresis and thin layer chromatography were used for analysis, showing that DTPA, EDTA and 1-methyl-EDTA preparations contained most of the 99m-Tc radioactivity in the chelate form. Kinetic studies showed that binding to 1-phenyl-EDTA was slow. All compounds migrated towards the anode on electrophoresis, enabling separation from free pertechnetate and reduced 99mTc. Quantitative distribution studies in mice and computerized renograms in rabbits showed that renal clearance was the main excretory route, but all compounds were cleared more slowly than 131-hippuran. The presence of the lipophilic phenyl group in the EDTA molecule produced excretion partially by the biliary route. These complexes belong to a series of bifunctional chelates which has the potential to produce new 99mTc-radiopharmaceuticals having the in vivo stability of 99Tc-EDTA.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 159-169 |
| Number of pages | 11 |
| Journal | International Journal of Nuclear Medicine and Biology |
| Volume | 8 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - 1981 |
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ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Technetium-99m complexes of EDTA analogs : Studies of the radiochemistry and biodistribution. / Baker, Richmond J.; Diamanti, Carol I.; Goodwin, David A.; Meares, Claude F.
In: International Journal of Nuclear Medicine and Biology, Vol. 8, No. 2-3, 1981, p. 159-169.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Technetium-99m complexes of EDTA analogs
T2 - Studies of the radiochemistry and biodistribution
AU - Baker, Richmond J.
AU - Diamanti, Carol I.
AU - Goodwin, David A.
AU - Meares, Claude F.
PY - 1981
Y1 - 1981
N2 - The preparation of technetium-99m aminopolycarboxylate complexes was carried out under anerobic conditions using stannous ions as the reducing agent. Electrophoresis and thin layer chromatography were used for analysis, showing that DTPA, EDTA and 1-methyl-EDTA preparations contained most of the 99m-Tc radioactivity in the chelate form. Kinetic studies showed that binding to 1-phenyl-EDTA was slow. All compounds migrated towards the anode on electrophoresis, enabling separation from free pertechnetate and reduced 99mTc. Quantitative distribution studies in mice and computerized renograms in rabbits showed that renal clearance was the main excretory route, but all compounds were cleared more slowly than 131-hippuran. The presence of the lipophilic phenyl group in the EDTA molecule produced excretion partially by the biliary route. These complexes belong to a series of bifunctional chelates which has the potential to produce new 99mTc-radiopharmaceuticals having the in vivo stability of 99Tc-EDTA.
AB - The preparation of technetium-99m aminopolycarboxylate complexes was carried out under anerobic conditions using stannous ions as the reducing agent. Electrophoresis and thin layer chromatography were used for analysis, showing that DTPA, EDTA and 1-methyl-EDTA preparations contained most of the 99m-Tc radioactivity in the chelate form. Kinetic studies showed that binding to 1-phenyl-EDTA was slow. All compounds migrated towards the anode on electrophoresis, enabling separation from free pertechnetate and reduced 99mTc. Quantitative distribution studies in mice and computerized renograms in rabbits showed that renal clearance was the main excretory route, but all compounds were cleared more slowly than 131-hippuran. The presence of the lipophilic phenyl group in the EDTA molecule produced excretion partially by the biliary route. These complexes belong to a series of bifunctional chelates which has the potential to produce new 99mTc-radiopharmaceuticals having the in vivo stability of 99Tc-EDTA.
UR - http://www.scopus.com/inward/record.url?scp=0019731879&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019731879&partnerID=8YFLogxK
U2 - 10.1016/0047-0740(81)90070-X
DO - 10.1016/0047-0740(81)90070-X
M3 - Article
C2 - 6797978
AN - SCOPUS:0019731879
VL - 8
SP - 159
EP - 169
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
SN - 0969-8051
IS - 2-3
ER -