Technetium-99m complexes of EDTA analogs: Studies of the radiochemistry and biodistribution

Richmond J. Baker, Carol I. Diamanti, David A. Goodwin, Claude F. Meares

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The preparation of technetium-99m aminopolycarboxylate complexes was carried out under anerobic conditions using stannous ions as the reducing agent. Electrophoresis and thin layer chromatography were used for analysis, showing that DTPA, EDTA and 1-methyl-EDTA preparations contained most of the 99m-Tc radioactivity in the chelate form. Kinetic studies showed that binding to 1-phenyl-EDTA was slow. All compounds migrated towards the anode on electrophoresis, enabling separation from free pertechnetate and reduced 99mTc. Quantitative distribution studies in mice and computerized renograms in rabbits showed that renal clearance was the main excretory route, but all compounds were cleared more slowly than 131-hippuran. The presence of the lipophilic phenyl group in the EDTA molecule produced excretion partially by the biliary route. These complexes belong to a series of bifunctional chelates which has the potential to produce new 99mTc-radiopharmaceuticals having the in vivo stability of 99Tc-EDTA.

Original languageEnglish (US)
Pages (from-to)159-169
Number of pages11
JournalInternational Journal of Nuclear Medicine and Biology
Issue number2-3
StatePublished - 1981

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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