TCRγδ cells: Mysterious cells of the immune system

Roger Sciammas, Y. Tatsumi, A. I. Sperling, K. Arunan, Jeffrey A. Bluestone

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

γδ cells participate in pathogenic infections and autoimmune conditions, yet, almost a decade after their discovery, little is known regarding their TCR repertoire or effector functions. Unlike MHC-restricted antigen recognition employed by TCRαβ cells, TCRγδ cells can recognize whole unprocessed antigens in an MHC-independent manner. The nature of positive and negative selection used to shape the repertoire of TCRγδ cells is unclear, especially in the nonlymphoid tissues where these cells predominate. While TCRγδ cells express an activated phenotype and are present in pathological conditions, their roles in immunological protection is unknown. This review will focus on our efforts to study these issues of TCRγδ biology.

Original languageEnglish (US)
Pages (from-to)268-279
Number of pages12
JournalImmunologic Research
Volume13
Issue number4
DOIs
StatePublished - Dec 1994
Externally publishedYes

Keywords

  • Antigen recognition
  • Clonal selection
  • Immunological protection
  • T cell receptor
  • TCRγδ cells

ASJC Scopus subject areas

  • Immunology

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    Sciammas, R., Tatsumi, Y., Sperling, A. I., Arunan, K., & Bluestone, J. A. (1994). TCRγδ cells: Mysterious cells of the immune system. Immunologic Research, 13(4), 268-279. https://doi.org/10.1007/BF02935618