Taurine status in normal dogs fed a commercial diet associated with taurine deficiency and dilated cardiomyopathy

C. L. Tôrres, R. C. Backus, Andrea J Fascetti, Quinton Rogers

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Taurine (Tau) deficiencies have been associated with the feeding of commercial lamb-meal and rice diets to dogs. We hypothesized that the poor digestibility of some lamb-meals may limit sulphur amino acids availability for Tau synthesis and/or increase of Tau degradation in the gut. Growing dogs were fed either a lamb-meal-based (Diet A) or poultry by-product-based (Diet B) commercial diet. Plasma, whole blood and urinary Tau were measured for 22 weeks. Plasma and whole blood Tau concentrations were similar between the groups throughout the study. Urinary excretion of Tau in dogs fed diet A was 3.2 times greater than that from dogs fed Diet B, suggesting greater renal reabsorption and the need for conservation of Tau in the Diet A group. Food restriction affected Tau status as indicted by a positive correlation of food intake and urinary Tau. Dogs fed Diet A were given antibiotics to inhibit bacterial activity in the gut. Increases in breath hydrogen, indicative of increased bacterial activity, correlated negatively with urinary Tau. Urinary Tau increased by 54% when methionine (Met) was supplemented to Diet A, supporting the suggestion of a low bioavailability of sulphur amino acids and/or an increased fecal loss of Tau in dogs consuming Diet A.

Original languageEnglish (US)
Pages (from-to)359-372
Number of pages14
JournalJournal of Animal Physiology and Animal Nutrition
Volume87
Issue number9-10
DOIs
StatePublished - Oct 2003

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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