Taste aversion disruption by drug pretreatment: Dissociative and drug-specific effects

D. S. Cannon, T. B. Baker, Robert F Berman

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Disruption of taste aversion learning following the administration of the same drug prior to and during conditioning (intra-agent disruption) was shown to be greater than disruption following the administration of one drug prior to conditioning and another during conditioning (inter-agent disruption). Comparable dosages of ethanol and lithium chloride served as unconditioned stimuli. Inter-agent disruptions are attributed to a dissociation of conditioned and unconditioned stimuli, while intra-agent disruptions are attributed to both a dissociative effect and drug-specific effects. Intra-agent disruptions are measure of tolerance, suggesting tolerance constitutes at least a portion of the drug-specific effects.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalPharmacology, Biochemistry and Behavior
Volume6
Issue number1
DOIs
StatePublished - 1977
Externally publishedYes

Keywords

  • Ethanol
  • Lithium chloride
  • Taste aversion
  • Taste aversion disruption
  • Tolerance

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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