Abstract
Disruption of taste aversion learning following the administration of the same drug prior to and during conditioning (intra-agent disruption) was shown to be greater than disruption following the administration of one drug prior to conditioning and another during conditioning (inter-agent disruption). Comparable dosages of ethanol and lithium chloride served as unconditioned stimuli. Inter-agent disruptions are attributed to a dissociation of conditioned and unconditioned stimuli, while intra-agent disruptions are attributed to both a dissociative effect and drug-specific effects. Intra-agent disruptions are measure of tolerance, suggesting tolerance constitutes at least a portion of the drug-specific effects.
Original language | English (US) |
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Pages (from-to) | 93-100 |
Number of pages | 8 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 6 |
Issue number | 1 |
DOIs | |
State | Published - 1977 |
Externally published | Yes |
Keywords
- Ethanol
- Lithium chloride
- Taste aversion
- Taste aversion disruption
- Tolerance
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology