Targeting the Microbiota, From Irritable Bowel Syndrome to Mood Disorders: Focus on Probiotics and Prebiotics

Matteo M. Pusceddu, Kaitlin Murray, Melanie Gareau

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Purpose of Review: The crosstalk between the gut and the brain has revealed a complex communication system responsible for maintaining a proper gastrointestinal homeostasis as well as affect emotional mood and cognitive functions. Recent research has revealed that beneficial manipulation of the microbiota by probiotics and prebiotics represents an emerging and novel strategy for the treatment of a large spectrum of diseases ranging from visceral pain to mood disorders. The review critically evaluates current knowledge of the effects exerted by both probiotics and prebiotics in irritable bowel syndrome (IBS) and mood disorders such as anxiety and depression. Recent Findings: Relevant literature was identified through a search of MEDLINE via PubMed using the following words, “probiotics”, “prebiotics”, “microbiota”, and “gut-brain axis” in combination with “stress”, “depression”, “IBS”, and “anxiety”. A number of trials have shown efficacy of probiotics and prebiotics in ameliorating both IBS-related symptoms and emotional states. However, limitations have been found especially due to the small number of clinical studies, studies’ design, patient sample size, and placebo effect. Summary: Nonetheless, current finding supports the view that beneficial manipulation of the microbiota through both probiotics and prebiotics intake represents a novel attractive strategy to treat gut-brain axis disorders such as IBS and depression.

Original languageEnglish (US)
JournalCurrent Pathobiology Reports
Issue number1
StatePublished - Mar 1 2018


  • Anxiety
  • Depression
  • Gut-brain axis
  • IBS
  • Prebiotics
  • Probiotics

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Pathology and Forensic Medicine
  • Cancer Research


Dive into the research topics of 'Targeting the Microbiota, From Irritable Bowel Syndrome to Mood Disorders: Focus on Probiotics and Prebiotics'. Together they form a unique fingerprint.

Cite this