Abstract
A successful strategy for the treatment of hepatic damage should be based on the use of nontoxic drugs with a high therapeutic index and safety profile, as well as selective targeting delivery. To achieve these goals, several biological and synthetic vehicles have been formulated with a wide range of chemical and physical properties. These vectors allow the delivery of either traditional drugs or genetic material to the cells. Despite remarkable progress, the design of an ideal carrier is still to be accomplished. Safety issues concerning viral vectors and low efficiency of synthetic delivery systems are the main limitations of present vectors. Once these problems are overcome, the liver-specific targeting systems will provide new opportunities to treat a vast range of hepatic diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 950-954 |
| Number of pages | 5 |
| Journal | Alcoholism: Clinical and Experimental Research |
| Volume | 23 |
| Issue number | 5 |
| State | Published - May 1999 |
| Externally published | Yes |
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Keywords
- Drug Delivery
- Gene Therapy
- Liposomes
- Liver Diseases
- SV-40
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Toxicology
Cite this
Targeting of therapeutics to the liver : Liposomes and viral vectors. / Di Campli, C.; Wu, J.; Zern, Mark A.
In: Alcoholism: Clinical and Experimental Research, Vol. 23, No. 5, 05.1999, p. 950-954.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Targeting of therapeutics to the liver
T2 - Liposomes and viral vectors
AU - Di Campli, C.
AU - Wu, J.
AU - Zern, Mark A
PY - 1999/5
Y1 - 1999/5
N2 - A successful strategy for the treatment of hepatic damage should be based on the use of nontoxic drugs with a high therapeutic index and safety profile, as well as selective targeting delivery. To achieve these goals, several biological and synthetic vehicles have been formulated with a wide range of chemical and physical properties. These vectors allow the delivery of either traditional drugs or genetic material to the cells. Despite remarkable progress, the design of an ideal carrier is still to be accomplished. Safety issues concerning viral vectors and low efficiency of synthetic delivery systems are the main limitations of present vectors. Once these problems are overcome, the liver-specific targeting systems will provide new opportunities to treat a vast range of hepatic diseases.
AB - A successful strategy for the treatment of hepatic damage should be based on the use of nontoxic drugs with a high therapeutic index and safety profile, as well as selective targeting delivery. To achieve these goals, several biological and synthetic vehicles have been formulated with a wide range of chemical and physical properties. These vectors allow the delivery of either traditional drugs or genetic material to the cells. Despite remarkable progress, the design of an ideal carrier is still to be accomplished. Safety issues concerning viral vectors and low efficiency of synthetic delivery systems are the main limitations of present vectors. Once these problems are overcome, the liver-specific targeting systems will provide new opportunities to treat a vast range of hepatic diseases.
KW - Drug Delivery
KW - Gene Therapy
KW - Liposomes
KW - Liver Diseases
KW - SV-40
UR - http://www.scopus.com/inward/record.url?scp=0032994427&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032994427&partnerID=8YFLogxK
M3 - Article
C2 - 10371421
AN - SCOPUS:0032994427
VL - 23
SP - 950
EP - 954
JO - Alcoholism: Clinical and Experimental Research
JF - Alcoholism: Clinical and Experimental Research
SN - 0145-6008
IS - 5
ER -