Targeting NF-κB signaling with protein Kinase C agonists as an emerging strategy for combating HIV latency

Guochun Jiang, Satya Dandekar

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Highly active antiretroviral therapy (HAART) is very effective in suppressing HIV-1 replication and restoring immune functions in HIV-infected individuals. However, it fails to eradicate the latent viral reservoirs and fully resolve chronic inflammation in HIV infection. The "shock-and-kill" strategy was recently proposed to induce latent HIV expression in the presence of HAART. Recent studies have shown that the protein kinase C (PKC) agonists are highly potent in inducing latent HIV expression from the viral reservoirs in vitro and ex vivo and in protecting primary CD4<sup>+</sup> T cells from HIV infection through down-modulation of their HIV coreceptor expression. The PKC agonists are excellent candidates for advancing to clinical HIV eradication strategies. This article will present a critical review of the structure and function of known PKC agonists, their mechanisms for the reactivation of latent HIV expression, and the potential of these compounds for advancing clinical HIV eradication strategies.

Original languageEnglish (US)
Pages (from-to)4-12
Number of pages9
JournalAIDS Research and Human Retroviruses
Volume31
Issue number1
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Immunology
  • Virology
  • Infectious Diseases

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