Targeting neutrophils in ischemic stroke: Translational insights from experimental studies

Glen C. Jickling, Da Liu, Bradley Ander, Boryana Stamova, Xinhua Zhan, Frank R Sharp

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Neutrophils have key roles in ischemic brain injury, thrombosis, and atherosclerosis. As such, neutrophils are of great interest as targets to treat and prevent ischemic stroke. After stroke, neutrophils respond rapidly promoting blood-brain barrier disruption, cerebral edema, and brain injury. A surge of neutrophil-derived reactive oxygen species, proteases, and cytokines are released as neutrophils interact with cerebral endothelium. Neutrophils also are linked to the major processes that cause ischemic stroke, thrombosis, and atherosclerosis. Thrombosis is promoted through interactions with platelets, clotting factors, and release of prothrombotic molecules. In atherosclerosis, neutrophils promote plaque formation and rupture by generating oxidized-low density lipoprotein, enhancing monocyte infiltration, and degrading the fibrous cap. In experimental studies targeting neutrophils can improve stroke. However, early human studies have been met with challenges, and suggest that selective targeting of neutrophils may be required. Several properties of neutrophil are beneficial and thus may important to preserve in patients with stroke including antimicrobial, antiinflammatory, and neuroprotective functions.

Original languageEnglish (US)
Pages (from-to)888-901
Number of pages14
JournalJournal of Cerebral Blood Flow and Metabolism
Volume35
Issue number6
DOIs
StatePublished - Jun 1 2015

Fingerprint

Neutrophils
Stroke
Atherosclerosis
Brain Injuries
Thrombosis
Intracranial Thrombosis
Blood Coagulation Factors
Brain Edema
Blood-Brain Barrier
Endothelium
Rupture
Monocytes
Reactive Oxygen Species
Peptide Hydrolases
Anti-Inflammatory Agents
Blood Platelets
Cytokines

Keywords

  • atherosclerosis
  • cerebral ischemia
  • immune system
  • neutrophil
  • stroke
  • thrombus

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology

Cite this

Targeting neutrophils in ischemic stroke : Translational insights from experimental studies. / Jickling, Glen C.; Liu, Da; Ander, Bradley; Stamova, Boryana; Zhan, Xinhua; Sharp, Frank R.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 35, No. 6, 01.06.2015, p. 888-901.

Research output: Contribution to journalArticle

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