Targeting head and neck cancer stem cells: Current advances and future challenges

A. C. Birkeland, J. H. Owen, M. E. Prince

Research output: Contribution to journalReview articlepeer-review

16 Scopus citations


Cancer stem cells (CSCs), or tumor-initiating cells, comprise a subset of tumor cells with demonstrated ability for tumor growth, invasion, metastasis, and resistance to chemotherapy and radiation. Targeting of CSCs remains an attractive yet elusive therapeutic option, with the goal of increasing specificity and effectiveness in tumor eradication, as well as decreasing off-target or systemic toxicity. Research into further characterization and targeted therapy toward head and neck CSCs is an active and rapidly evolving field. This review discusses the current state of research into therapy against head and neck CSCs and future directions for targeted therapy.

Original languageEnglish (US)
Pages (from-to)1516-1523
Number of pages8
JournalJournal of Dental Research
Issue number11
StatePublished - Nov 1 2015
Externally publishedYes


  • cancer biology
  • cancer genes
  • characteristics
  • treatment
  • tumor initiating cells

ASJC Scopus subject areas

  • Dentistry(all)


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