Abstract
Epigenetic mechanisms, including DNA methylation and histone modifications, account for a highly sophisticated regulatory system that is fundamental to the regulation of many cellular processes, including gene and microRNA expression, DNA-protein interactions, suppression of transposable element mobility, cellular differentiation, embryogenesis, X-chromosome inactivation, and genomic imprinting. Extensive data has shown that epigenetic changes are associated with multiple human diseases. In the context of autoimmune diseases, especially systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS), evidence suggests that epigenetic changes may in fact play a causal role in the pathophysiology of these disorders. Understanding the epigenetics of autoimmune diseases may provide insights into clinical applications implicated in diagnostic, prognostic biomarkers and the prediction of drug responses, as well as new therapeutic interventions that may modulate disease-related epigenetic alterations and thereby improve patient outcomes.
| Original language | English (US) |
|---|---|
| Title of host publication | Epigenetics and Dermatology |
| Publisher | Elsevier Inc. |
| Pages | 409-441 |
| Number of pages | 33 |
| ISBN (Print) | 9780128012727, 9780128009574 |
| DOIs | |
| State | Published - Feb 17 2015 |
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Keywords
- DNA methylation
- Epigenetic perturbations
- Histone modifications
- Multiple sclerosis
- Rheumatoid arthritis
- Systemic lupus erythematosus
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Targeting Epigenetics in the Development of New Diagnostic Applications-Lessons from Autoimmune Diseases. / Chen, Hui Min; Chedin, Frederic; Chang, Christopher; Leung, Patrick S.
Epigenetics and Dermatology. Elsevier Inc., 2015. p. 409-441.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Targeting Epigenetics in the Development of New Diagnostic Applications-Lessons from Autoimmune Diseases
AU - Chen, Hui Min
AU - Chedin, Frederic
AU - Chang, Christopher
AU - Leung, Patrick S
PY - 2015/2/17
Y1 - 2015/2/17
N2 - Epigenetic mechanisms, including DNA methylation and histone modifications, account for a highly sophisticated regulatory system that is fundamental to the regulation of many cellular processes, including gene and microRNA expression, DNA-protein interactions, suppression of transposable element mobility, cellular differentiation, embryogenesis, X-chromosome inactivation, and genomic imprinting. Extensive data has shown that epigenetic changes are associated with multiple human diseases. In the context of autoimmune diseases, especially systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS), evidence suggests that epigenetic changes may in fact play a causal role in the pathophysiology of these disorders. Understanding the epigenetics of autoimmune diseases may provide insights into clinical applications implicated in diagnostic, prognostic biomarkers and the prediction of drug responses, as well as new therapeutic interventions that may modulate disease-related epigenetic alterations and thereby improve patient outcomes.
AB - Epigenetic mechanisms, including DNA methylation and histone modifications, account for a highly sophisticated regulatory system that is fundamental to the regulation of many cellular processes, including gene and microRNA expression, DNA-protein interactions, suppression of transposable element mobility, cellular differentiation, embryogenesis, X-chromosome inactivation, and genomic imprinting. Extensive data has shown that epigenetic changes are associated with multiple human diseases. In the context of autoimmune diseases, especially systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS), evidence suggests that epigenetic changes may in fact play a causal role in the pathophysiology of these disorders. Understanding the epigenetics of autoimmune diseases may provide insights into clinical applications implicated in diagnostic, prognostic biomarkers and the prediction of drug responses, as well as new therapeutic interventions that may modulate disease-related epigenetic alterations and thereby improve patient outcomes.
KW - DNA methylation
KW - Epigenetic perturbations
KW - Histone modifications
KW - Multiple sclerosis
KW - Rheumatoid arthritis
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=84940053574&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940053574&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-800957-4.00019-9
DO - 10.1016/B978-0-12-800957-4.00019-9
M3 - Chapter
AN - SCOPUS:84940053574
SN - 9780128012727
SN - 9780128009574
SP - 409
EP - 441
BT - Epigenetics and Dermatology
PB - Elsevier Inc.
ER -