Abstract
The expression of activating transcription factor 5 (ATF5) correlates negatively with patient survival in different types of cancer. ATF5 is important for the survival and proliferation of cancer cells, and can be targeted to selectively trigger cancer cell apoptosis while sparing normal cells. Cell-penetrating peptides combined with a dominant negative ATF5 cargo have recently shown efficacy against brain, breast, melanoma, and prostate cancers.
Original language | English (US) |
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Pages (from-to) | 471-474 |
Number of pages | 4 |
Journal | Trends in Cancer |
Volume | 3 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2017 |
Externally published | Yes |
Keywords
- apoptosis
- ATF5
- cancer
- cell-penetrating peptide
- CP-d/n-ATF5
- dominant negative
ASJC Scopus subject areas
- Oncology
- Cancer Research