Targeting ATF5 in Cancer

Research output: Contribution to journalShort survey

11 Scopus citations

Abstract

The expression of activating transcription factor 5 (ATF5) correlates negatively with patient survival in different types of cancer. ATF5 is important for the survival and proliferation of cancer cells, and can be targeted to selectively trigger cancer cell apoptosis while sparing normal cells. Cell-penetrating peptides combined with a dominant negative ATF5 cargo have recently shown efficacy against brain, breast, melanoma, and prostate cancers.

Original languageEnglish (US)
Pages (from-to)471-474
Number of pages4
JournalTrends in Cancer
Volume3
Issue number7
DOIs
StatePublished - Jul 1 2017

Keywords

  • apoptosis
  • ATF5
  • cancer
  • cell-penetrating peptide
  • CP-d/n-ATF5
  • dominant negative

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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