Targeted delivery of mesenchymal stem cells to the bone

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Osteoporosis is a disease of excess skeletal fragility that results from estrogen loss and aging. Age related bone loss has been attributed to both elevated bone resorption and insufficient bone formation. We developed a hybrid compound, LLP2A-Ale in which LLP2A has high affinity for the α4β1 integrin on mesenchymal stem cells (MSCs) and alendronate has high affinity for bone. When LLP2A-Ale was injected into mice, the compound directed MSCs to both trabecular and cortical bone surfaces and increased bone mass and bone strength. Additional studies are underway to further characterize this hybrid compound, LLP2A-Ale, and how it can be utilized for the treatment of bone loss resulting from hormone deficiency, aging, and inflammation and to augment bone fracture healing. This article is part of a Special Issue entitled "Stem Cells and Bone".

Original languageEnglish (US)
Pages (from-to)62-65
Number of pages4
JournalBone
Volume70
DOIs
StatePublished - Jan 1 2015

Keywords

  • Bone mass
  • Bone strength
  • Mesenchymal stem cells
  • Osteoblasts
  • Osteoporosis

ASJC Scopus subject areas

  • Physiology
  • Endocrinology, Diabetes and Metabolism
  • Histology

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