Abstract
A unique method to deliver a bioactive substance to the vascular endothelium uses ultrasound and delivery vehicles engineered to contain both gas and drug payload to localize drug delivery. The vehicles (called acoustically-active lipospheres or AALs) include a lipid shell, an oil layer to carry hydrophobic drugs which is associated with the lipid shell, and a small gas core. AALs are similar to ultrasound contrast agents: they can be non-destructively deflected using ultrasound radiation force, and fragmented with high-intensity ultrasound pulses. An optimized sequence of ultrasound pulses can deflect the AALs towards a vessel wall with radiation force and then disrupt them, painting their contents across the vascular endothelium. The resulting fragments can be anchored to endothelium with molecular targeting ligands that may be incorporated into the shell.
| Original language | English (US) |
|---|---|
| Title of host publication | Proceedings - IEEE Ultrasonics Symposium |
| Pages | 265-268 |
| Number of pages | 4 |
| Volume | 1 |
| DOIs | |
| State | Published - 2005 |
| Event | 2005 IEEE Ultrasonics Symposium - Rotterdam, Netherlands Duration: Sep 18 2005 → Sep 21 2005 |
Other
| Other | 2005 IEEE Ultrasonics Symposium |
|---|---|
| Country | Netherlands |
| City | Rotterdam |
| Period | 9/18/05 → 9/21/05 |
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Keywords
- Acoustically active lipospheres
- Drug delivery
- Radiation force
ASJC Scopus subject areas
- Engineering(all)
Cite this
Targeted chemotherapy delivery with ultrasound. / Shortencarier, Michaelann; Dayton, Paul; Ferrara, Katherine; Matsunaga, Terry; LaBell, Rachel; Schumann, Patricia.
Proceedings - IEEE Ultrasonics Symposium. Vol. 1 2005. p. 265-268 1602846.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Targeted chemotherapy delivery with ultrasound
AU - Shortencarier, Michaelann
AU - Dayton, Paul
AU - Ferrara, Katherine
AU - Matsunaga, Terry
AU - LaBell, Rachel
AU - Schumann, Patricia
PY - 2005
Y1 - 2005
N2 - A unique method to deliver a bioactive substance to the vascular endothelium uses ultrasound and delivery vehicles engineered to contain both gas and drug payload to localize drug delivery. The vehicles (called acoustically-active lipospheres or AALs) include a lipid shell, an oil layer to carry hydrophobic drugs which is associated with the lipid shell, and a small gas core. AALs are similar to ultrasound contrast agents: they can be non-destructively deflected using ultrasound radiation force, and fragmented with high-intensity ultrasound pulses. An optimized sequence of ultrasound pulses can deflect the AALs towards a vessel wall with radiation force and then disrupt them, painting their contents across the vascular endothelium. The resulting fragments can be anchored to endothelium with molecular targeting ligands that may be incorporated into the shell.
AB - A unique method to deliver a bioactive substance to the vascular endothelium uses ultrasound and delivery vehicles engineered to contain both gas and drug payload to localize drug delivery. The vehicles (called acoustically-active lipospheres or AALs) include a lipid shell, an oil layer to carry hydrophobic drugs which is associated with the lipid shell, and a small gas core. AALs are similar to ultrasound contrast agents: they can be non-destructively deflected using ultrasound radiation force, and fragmented with high-intensity ultrasound pulses. An optimized sequence of ultrasound pulses can deflect the AALs towards a vessel wall with radiation force and then disrupt them, painting their contents across the vascular endothelium. The resulting fragments can be anchored to endothelium with molecular targeting ligands that may be incorporated into the shell.
KW - Acoustically active lipospheres
KW - Drug delivery
KW - Radiation force
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UR - http://www.scopus.com/inward/citedby.url?scp=33847112376&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2005.1602846
DO - 10.1109/ULTSYM.2005.1602846
M3 - Conference contribution
SN - 0780393821
SN - 9780780393820
VL - 1
SP - 265
EP - 268
BT - Proceedings - IEEE Ultrasonics Symposium
ER -