Targeted chemotherapy delivery with ultrasound

Michaelann Shortencarier, Paul Dayton, Katherine Ferrara, Terry Matsunaga, Rachel LaBell, Patricia Schumann

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

A unique method to deliver a bioactive substance to the vascular endothelium uses ultrasound and delivery vehicles engineered to contain both gas and drug payload to localize drug delivery. The vehicles (called acoustically-active lipospheres or AALs) include a lipid shell, an oil layer to carry hydrophobic drugs which is associated with the lipid shell, and a small gas core. AALs are similar to ultrasound contrast agents: they can be non-destructively deflected using ultrasound radiation force, and fragmented with high-intensity ultrasound pulses. An optimized sequence of ultrasound pulses can deflect the AALs towards a vessel wall with radiation force and then disrupt them, painting their contents across the vascular endothelium. The resulting fragments can be anchored to endothelium with molecular targeting ligands that may be incorporated into the shell.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE Ultrasonics Symposium
Pages265-268
Number of pages4
Volume1
DOIs
StatePublished - 2005
Event2005 IEEE Ultrasonics Symposium - Rotterdam, Netherlands
Duration: Sep 18 2005Sep 21 2005

Other

Other2005 IEEE Ultrasonics Symposium
CountryNetherlands
CityRotterdam
Period9/18/059/21/05

Fingerprint

Chemotherapy
Ultrasonics
Lipids
Radiation
Painting
Drug delivery
Gases
Ligands

Keywords

  • Acoustically active lipospheres
  • Drug delivery
  • Radiation force

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Shortencarier, M., Dayton, P., Ferrara, K., Matsunaga, T., LaBell, R., & Schumann, P. (2005). Targeted chemotherapy delivery with ultrasound. In Proceedings - IEEE Ultrasonics Symposium (Vol. 1, pp. 265-268). [1602846] https://doi.org/10.1109/ULTSYM.2005.1602846

Targeted chemotherapy delivery with ultrasound. / Shortencarier, Michaelann; Dayton, Paul; Ferrara, Katherine; Matsunaga, Terry; LaBell, Rachel; Schumann, Patricia.

Proceedings - IEEE Ultrasonics Symposium. Vol. 1 2005. p. 265-268 1602846.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Shortencarier, M, Dayton, P, Ferrara, K, Matsunaga, T, LaBell, R & Schumann, P 2005, Targeted chemotherapy delivery with ultrasound. in Proceedings - IEEE Ultrasonics Symposium. vol. 1, 1602846, pp. 265-268, 2005 IEEE Ultrasonics Symposium, Rotterdam, Netherlands, 9/18/05. https://doi.org/10.1109/ULTSYM.2005.1602846
Shortencarier M, Dayton P, Ferrara K, Matsunaga T, LaBell R, Schumann P. Targeted chemotherapy delivery with ultrasound. In Proceedings - IEEE Ultrasonics Symposium. Vol. 1. 2005. p. 265-268. 1602846 https://doi.org/10.1109/ULTSYM.2005.1602846
Shortencarier, Michaelann ; Dayton, Paul ; Ferrara, Katherine ; Matsunaga, Terry ; LaBell, Rachel ; Schumann, Patricia. / Targeted chemotherapy delivery with ultrasound. Proceedings - IEEE Ultrasonics Symposium. Vol. 1 2005. pp. 265-268
@inproceedings{c0e4bd23a36a4e83b14ebeff58d6b64f,
title = "Targeted chemotherapy delivery with ultrasound",
abstract = "A unique method to deliver a bioactive substance to the vascular endothelium uses ultrasound and delivery vehicles engineered to contain both gas and drug payload to localize drug delivery. The vehicles (called acoustically-active lipospheres or AALs) include a lipid shell, an oil layer to carry hydrophobic drugs which is associated with the lipid shell, and a small gas core. AALs are similar to ultrasound contrast agents: they can be non-destructively deflected using ultrasound radiation force, and fragmented with high-intensity ultrasound pulses. An optimized sequence of ultrasound pulses can deflect the AALs towards a vessel wall with radiation force and then disrupt them, painting their contents across the vascular endothelium. The resulting fragments can be anchored to endothelium with molecular targeting ligands that may be incorporated into the shell.",
keywords = "Acoustically active lipospheres, Drug delivery, Radiation force",
author = "Michaelann Shortencarier and Paul Dayton and Katherine Ferrara and Terry Matsunaga and Rachel LaBell and Patricia Schumann",
year = "2005",
doi = "10.1109/ULTSYM.2005.1602846",
language = "English (US)",
isbn = "0780393821",
volume = "1",
pages = "265--268",
booktitle = "Proceedings - IEEE Ultrasonics Symposium",

}

TY - GEN

T1 - Targeted chemotherapy delivery with ultrasound

AU - Shortencarier, Michaelann

AU - Dayton, Paul

AU - Ferrara, Katherine

AU - Matsunaga, Terry

AU - LaBell, Rachel

AU - Schumann, Patricia

PY - 2005

Y1 - 2005

N2 - A unique method to deliver a bioactive substance to the vascular endothelium uses ultrasound and delivery vehicles engineered to contain both gas and drug payload to localize drug delivery. The vehicles (called acoustically-active lipospheres or AALs) include a lipid shell, an oil layer to carry hydrophobic drugs which is associated with the lipid shell, and a small gas core. AALs are similar to ultrasound contrast agents: they can be non-destructively deflected using ultrasound radiation force, and fragmented with high-intensity ultrasound pulses. An optimized sequence of ultrasound pulses can deflect the AALs towards a vessel wall with radiation force and then disrupt them, painting their contents across the vascular endothelium. The resulting fragments can be anchored to endothelium with molecular targeting ligands that may be incorporated into the shell.

AB - A unique method to deliver a bioactive substance to the vascular endothelium uses ultrasound and delivery vehicles engineered to contain both gas and drug payload to localize drug delivery. The vehicles (called acoustically-active lipospheres or AALs) include a lipid shell, an oil layer to carry hydrophobic drugs which is associated with the lipid shell, and a small gas core. AALs are similar to ultrasound contrast agents: they can be non-destructively deflected using ultrasound radiation force, and fragmented with high-intensity ultrasound pulses. An optimized sequence of ultrasound pulses can deflect the AALs towards a vessel wall with radiation force and then disrupt them, painting their contents across the vascular endothelium. The resulting fragments can be anchored to endothelium with molecular targeting ligands that may be incorporated into the shell.

KW - Acoustically active lipospheres

KW - Drug delivery

KW - Radiation force

UR - http://www.scopus.com/inward/record.url?scp=33847112376&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847112376&partnerID=8YFLogxK

U2 - 10.1109/ULTSYM.2005.1602846

DO - 10.1109/ULTSYM.2005.1602846

M3 - Conference contribution

SN - 0780393821

SN - 9780780393820

VL - 1

SP - 265

EP - 268

BT - Proceedings - IEEE Ultrasonics Symposium

ER -