Targeted chemotherapy delivery with ultrasound

Michaelann Shortencarier, Paul Dayton, Katherine Ferrara, Terry Matsunaga, Rachel LaBell, Patricia Schumann

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

A unique method to deliver a bioactive substance to the vascular endothelium uses ultrasound and delivery vehicles engineered to contain both gas and drug payload to localize drug delivery. The vehicles (called acoustically-active lipospheres or AALs) include a lipid shell, an oil layer to carry hydrophobic drugs which is associated with the lipid shell, and a small gas core. AALs are similar to ultrasound contrast agents: they can be non-destructively deflected using ultrasound radiation force, and fragmented with high-intensity ultrasound pulses. An optimized sequence of ultrasound pulses can deflect the AALs towards a vessel wall with radiation force and then disrupt them, painting their contents across the vascular endothelium. The resulting fragments can be anchored to endothelium with molecular targeting ligands that may be incorporated into the shell.

Original languageEnglish (US)
Title of host publicationProceedings - IEEE Ultrasonics Symposium
Pages265-268
Number of pages4
Volume1
DOIs
StatePublished - 2005
Event2005 IEEE Ultrasonics Symposium - Rotterdam, Netherlands
Duration: Sep 18 2005Sep 21 2005

Other

Other2005 IEEE Ultrasonics Symposium
CountryNetherlands
CityRotterdam
Period9/18/059/21/05

Keywords

  • Acoustically active lipospheres
  • Drug delivery
  • Radiation force

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Shortencarier, M., Dayton, P., Ferrara, K., Matsunaga, T., LaBell, R., & Schumann, P. (2005). Targeted chemotherapy delivery with ultrasound. In Proceedings - IEEE Ultrasonics Symposium (Vol. 1, pp. 265-268). [1602846] https://doi.org/10.1109/ULTSYM.2005.1602846