Target cells in vaginal HIV transmission

Chris J Miller, Robin J. Shattock

Research output: Contribution to journalArticlepeer-review

187 Scopus citations


Understanding the mechanisms of HIV transmission to women will be crucial to the development of effective strategies to curb this epidemic. Current data suggest that HIV has at least two routes to penetrate the vaginal epithelium and reach lymphoid tissues, trans-epithelial migration of infected Langerhans cells or virus penetration into the lamina propria through loss of epithelial integrity resulting in direct infection of lymphocytes, dendritic cells and macrophages.

Original languageEnglish (US)
Pages (from-to)59-67
Number of pages9
JournalMicrobes and Infection
Issue number1
StatePublished - Jan 1 2003


  • Epithelium
  • Inflammation
  • Langerhans cells
  • SIV

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases


Dive into the research topics of 'Target cells in vaginal HIV transmission'. Together they form a unique fingerprint.

Cite this