Target cells in vaginal HIV transmission

Chris J Miller, Robin J. Shattock

Research output: Contribution to journalArticle

177 Citations (Scopus)

Abstract

Understanding the mechanisms of HIV transmission to women will be crucial to the development of effective strategies to curb this epidemic. Current data suggest that HIV has at least two routes to penetrate the vaginal epithelium and reach lymphoid tissues, trans-epithelial migration of infected Langerhans cells or virus penetration into the lamina propria through loss of epithelial integrity resulting in direct infection of lymphocytes, dendritic cells and macrophages.

Original languageEnglish (US)
Pages (from-to)59-67
Number of pages9
JournalMicrobes and Infection
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2003

Fingerprint

HIV
Langerhans Cells
Lymphoid Tissue
Dendritic Cells
Mucous Membrane
Epithelium
Macrophages
Lymphocytes
Viruses
Infection

Keywords

  • Epithelium
  • Inflammation
  • Langerhans cells
  • SIV

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

Cite this

Target cells in vaginal HIV transmission. / Miller, Chris J; Shattock, Robin J.

In: Microbes and Infection, Vol. 5, No. 1, 01.01.2003, p. 59-67.

Research output: Contribution to journalArticle

Miller, Chris J ; Shattock, Robin J. / Target cells in vaginal HIV transmission. In: Microbes and Infection. 2003 ; Vol. 5, No. 1. pp. 59-67.
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