Target cells in vaginal HIV transmission

Chris J Miller, Robin J. Shattock

Research output: Contribution to journalArticle

180 Scopus citations

Abstract

Understanding the mechanisms of HIV transmission to women will be crucial to the development of effective strategies to curb this epidemic. Current data suggest that HIV has at least two routes to penetrate the vaginal epithelium and reach lymphoid tissues, trans-epithelial migration of infected Langerhans cells or virus penetration into the lamina propria through loss of epithelial integrity resulting in direct infection of lymphocytes, dendritic cells and macrophages.

Original languageEnglish (US)
Pages (from-to)59-67
Number of pages9
JournalMicrobes and Infection
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2003

Keywords

  • Epithelium
  • Inflammation
  • Langerhans cells
  • SIV

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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