Tamoxifen as an antifertility agent in the long-tailed macaque (Macaca fascicularis)

Alice F Tarantal, Andrew G Hendrickx, Stephen A. Matlin, Bill L. Lasley, Quin Quin Gu, Charles A A Thomas, Pamela M. Vince, Paul F A Van Look

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Abstract

The potential use of tamoxifen, a nonsteroidal antiestrogen, as an antifertility agent was studied in the long-tailed macaque (Macaca fascicularis). Twenty-six cycling females were bred, then treated with a single oral dose of tamoxifen (5 mg/kg) (N = 13) or vehicle (N = 13) on day 4 post-ovulation. Serum progesterone (P4) and tamoxifen concentrations were evaluated on post-ovulation days 4, 8, 12, 16, and 18. No effects of treatment were observed on P4 concentrations or on the fertility rate - pregnancy was achieved in 4/13 controls (31%) and 6/13 treated females (46%). Analysis for serum tamoxifen concentrations in samples collected during the fertility and a supplemental pharmacokinetic study (N = 3; single oral dose of 10 mg/kg; urine and serum evaluated) failed to reveal any detectable tamoxifen levels. It was concluded that (1) absorption of tamoxifen may be negligible under the described treatment regimens or (2) tamoxifen metabolism/clearance occurs at a rapid rate.

Original languageEnglish (US)
Pages (from-to)307-316
Number of pages10
JournalContraception
Volume47
Issue number3
DOIs
StatePublished - 1993

Fingerprint

Macaca fascicularis
Macaca
Tamoxifen
Ovulation
Serum
Estrogen Receptor Modulators
Birth Rate
Progesterone
Fertility
Pharmacokinetics
Urine
Pregnancy

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Tarantal, A. F., Hendrickx, A. G., Matlin, S. A., Lasley, B. L., Gu, Q. Q., Thomas, C. A. A., ... Van Look, P. F. A. (1993). Tamoxifen as an antifertility agent in the long-tailed macaque (Macaca fascicularis). Contraception, 47(3), 307-316. https://doi.org/10.1016/0010-7824(93)90047-B

Tamoxifen as an antifertility agent in the long-tailed macaque (Macaca fascicularis). / Tarantal, Alice F; Hendrickx, Andrew G; Matlin, Stephen A.; Lasley, Bill L.; Gu, Quin Quin; Thomas, Charles A A; Vince, Pamela M.; Van Look, Paul F A.

In: Contraception, Vol. 47, No. 3, 1993, p. 307-316.

Research output: Contribution to journalArticle

Tarantal, AF, Hendrickx, AG, Matlin, SA, Lasley, BL, Gu, QQ, Thomas, CAA, Vince, PM & Van Look, PFA 1993, 'Tamoxifen as an antifertility agent in the long-tailed macaque (Macaca fascicularis)', Contraception, vol. 47, no. 3, pp. 307-316. https://doi.org/10.1016/0010-7824(93)90047-B
Tarantal, Alice F ; Hendrickx, Andrew G ; Matlin, Stephen A. ; Lasley, Bill L. ; Gu, Quin Quin ; Thomas, Charles A A ; Vince, Pamela M. ; Van Look, Paul F A. / Tamoxifen as an antifertility agent in the long-tailed macaque (Macaca fascicularis). In: Contraception. 1993 ; Vol. 47, No. 3. pp. 307-316.
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