Talus osteochondritis dissecans: Treatment with matrix-based autologous chondrocyte implantation

Eric Giza, Ryan Nathe, Jason Kim

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Osteochondral lesions of the talus are a common occurrence especially in sports, occurring 6.5% of all ankle sprains. Inherently talar cartilage is unable to repair itself secondary to the lack of blood supply, and it is incapable of healing through the typical inflammatory phase. Such damage can be irreversible and lead to the onset of osteoarthritis. There are many surgical repair options for osteochondral lesion of the talus. However, a trial of conservative therapy is warranted especially because studies have shown that this does not adversely affect the outcome of the surgery. Ideally, the treatment options should focus on restoring the articular cartilage surface, normal hyaline cartridge, and improvement of patients symptoms and function. Conventional surgical techniques, such as drilling and microfractures, try to address these goals through bone stimulation. However, these reparative techniques form disorganized fibrocartilage regenerate, which lacks the durability and many of the mechanical properties of the hyaline cartilage that normally covers the articular surfaces. In addition, poorer outcomes have been associated with lesions that are larger than 1 cm. There have been recent advances in surgical techniques to address these issues. The autologous chondrocyte implantation and matrix-based chondrocyte implantation use cells that are harvested from the body for the repair of chondral defect. These biological approaches for the treatment of chondral defects of the talus are introduced here.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalTechniques in Orthopaedics
Issue number4
StatePublished - Dec 2010


  • autologous chondrocyte implantation
  • implantation
  • matrix-based chondrocyte
  • osteochondral lesion
  • osteochondritis dissecans
  • talus

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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