Abstract
In certain circumstances, internalized receptors are able to continue signaling after endocytosis. Whistler et al. discuss how the interaction of heterotrimeric GTP-binding protein (G protein)-coupled receptors with arrestins and their subsequent endocytosis may contribute to activation of the mitogen-activated protein kinase pathway. This perspective delves into the role that scaffolds may play in organizing and specifying downstream signaling events that occur after internalization of G protein-coupled receptors.
| Original language | English (US) |
|---|---|
| Journal | Science"s STKE [electronic resource] : signal transduction knowledge environment |
| Volume | 2000 |
| Issue number | 47 |
| State | Published - Aug 29 2000 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)
Fingerprint Dive into the research topics of 'Tales from the crypt: evidence for heptahelical receptor signaling in the endocytic pathway.'. Together they form a unique fingerprint.
Cite this
Whistler, J., Beattie, E., & von Zastrow, M. (2000). Tales from the crypt: evidence for heptahelical receptor signaling in the endocytic pathway. Science"s STKE [electronic resource] : signal transduction knowledge environment, 2000(47).