Tales from the crypt: evidence for heptahelical receptor signaling in the endocytic pathway.

Jennifer Whistler, E. Beattie, M. von Zastrow

Research output: Contribution to journalReview article

Abstract

In certain circumstances, internalized receptors are able to continue signaling after endocytosis. Whistler et al. discuss how the interaction of heterotrimeric GTP-binding protein (G protein)-coupled receptors with arrestins and their subsequent endocytosis may contribute to activation of the mitogen-activated protein kinase pathway. This perspective delves into the role that scaffolds may play in organizing and specifying downstream signaling events that occur after internalization of G protein-coupled receptors.

Original languageEnglish (US)
JournalScience"s STKE [electronic resource] : signal transduction knowledge environment
Volume2000
Issue number47
StatePublished - Aug 29 2000
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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