Tales from the crypt: evidence for heptahelical receptor signaling in the endocytic pathway.

Jennifer Whistler, E. Beattie, M. von Zastrow

Research output: Contribution to journalReview article

Abstract

In certain circumstances, internalized receptors are able to continue signaling after endocytosis. Whistler et al. discuss how the interaction of heterotrimeric GTP-binding protein (G protein)-coupled receptors with arrestins and their subsequent endocytosis may contribute to activation of the mitogen-activated protein kinase pathway. This perspective delves into the role that scaffolds may play in organizing and specifying downstream signaling events that occur after internalization of G protein-coupled receptors.

Original languageEnglish (US)
JournalScience"s STKE [electronic resource] : signal transduction knowledge environment
Volume2000
Issue number47
StatePublished - Aug 29 2000
Externally publishedYes

Fingerprint

G-Protein-Coupled Receptors
Endocytosis
Arrestins
Heterotrimeric GTP-Binding Proteins
Mitogen-Activated Protein Kinases
Scaffolds
Chemical activation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tales from the crypt : evidence for heptahelical receptor signaling in the endocytic pathway. / Whistler, Jennifer; Beattie, E.; von Zastrow, M.

In: Science"s STKE [electronic resource] : signal transduction knowledge environment, Vol. 2000, No. 47, 29.08.2000.

Research output: Contribution to journalReview article

@article{1d0e715c57824740b49aaf495e8946a7,
title = "Tales from the crypt: evidence for heptahelical receptor signaling in the endocytic pathway.",
abstract = "In certain circumstances, internalized receptors are able to continue signaling after endocytosis. Whistler et al. discuss how the interaction of heterotrimeric GTP-binding protein (G protein)-coupled receptors with arrestins and their subsequent endocytosis may contribute to activation of the mitogen-activated protein kinase pathway. This perspective delves into the role that scaffolds may play in organizing and specifying downstream signaling events that occur after internalization of G protein-coupled receptors.",
author = "Jennifer Whistler and E. Beattie and {von Zastrow}, M.",
year = "2000",
month = "8",
day = "29",
language = "English (US)",
volume = "2000",
journal = "Science Signaling",
issn = "1937-9145",
publisher = "American Association for the Advancement of Science",
number = "47",

}

TY - JOUR

T1 - Tales from the crypt

T2 - evidence for heptahelical receptor signaling in the endocytic pathway.

AU - Whistler, Jennifer

AU - Beattie, E.

AU - von Zastrow, M.

PY - 2000/8/29

Y1 - 2000/8/29

N2 - In certain circumstances, internalized receptors are able to continue signaling after endocytosis. Whistler et al. discuss how the interaction of heterotrimeric GTP-binding protein (G protein)-coupled receptors with arrestins and their subsequent endocytosis may contribute to activation of the mitogen-activated protein kinase pathway. This perspective delves into the role that scaffolds may play in organizing and specifying downstream signaling events that occur after internalization of G protein-coupled receptors.

AB - In certain circumstances, internalized receptors are able to continue signaling after endocytosis. Whistler et al. discuss how the interaction of heterotrimeric GTP-binding protein (G protein)-coupled receptors with arrestins and their subsequent endocytosis may contribute to activation of the mitogen-activated protein kinase pathway. This perspective delves into the role that scaffolds may play in organizing and specifying downstream signaling events that occur after internalization of G protein-coupled receptors.

UR - http://www.scopus.com/inward/record.url?scp=0034730059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034730059&partnerID=8YFLogxK

M3 - Review article

C2 - 11752604

AN - SCOPUS:0034730059

VL - 2000

JO - Science Signaling

JF - Science Signaling

SN - 1937-9145

IS - 47

ER -