Abstract
In certain circumstances, internalized receptors are able to continue signaling after endocytosis. Whistler et al. discuss how the interaction of heterotrimeric GTP-binding protein (G protein)-coupled receptors with arrestins and their subsequent endocytosis may contribute to activation of the mitogen-activated protein kinase pathway. This perspective delves into the role that scaffolds may play in organizing and specifying downstream signaling events that occur after internalization of G protein-coupled receptors.
| Original language | English (US) |
|---|---|
| Journal | Science"s STKE [electronic resource] : signal transduction knowledge environment |
| Volume | 2000 |
| Issue number | 47 |
| State | Published - Aug 29 2000 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Tales from the crypt : evidence for heptahelical receptor signaling in the endocytic pathway. / Whistler, Jennifer; Beattie, E.; von Zastrow, M.
In: Science"s STKE [electronic resource] : signal transduction knowledge environment, Vol. 2000, No. 47, 29.08.2000.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Tales from the crypt
T2 - evidence for heptahelical receptor signaling in the endocytic pathway.
AU - Whistler, Jennifer
AU - Beattie, E.
AU - von Zastrow, M.
PY - 2000/8/29
Y1 - 2000/8/29
N2 - In certain circumstances, internalized receptors are able to continue signaling after endocytosis. Whistler et al. discuss how the interaction of heterotrimeric GTP-binding protein (G protein)-coupled receptors with arrestins and their subsequent endocytosis may contribute to activation of the mitogen-activated protein kinase pathway. This perspective delves into the role that scaffolds may play in organizing and specifying downstream signaling events that occur after internalization of G protein-coupled receptors.
AB - In certain circumstances, internalized receptors are able to continue signaling after endocytosis. Whistler et al. discuss how the interaction of heterotrimeric GTP-binding protein (G protein)-coupled receptors with arrestins and their subsequent endocytosis may contribute to activation of the mitogen-activated protein kinase pathway. This perspective delves into the role that scaffolds may play in organizing and specifying downstream signaling events that occur after internalization of G protein-coupled receptors.
UR - http://www.scopus.com/inward/record.url?scp=0034730059&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034730059&partnerID=8YFLogxK
M3 - Review article
C2 - 11752604
AN - SCOPUS:0034730059
VL - 2000
JO - Science Signaling
JF - Science Signaling
SN - 1937-9145
IS - 47
ER -