Tailored design and synthesis of heparan sulfate oligosaccharide analogues using sequential one-pot multienzyme systems

Yi Chen, Yanhong Li, Hai Yu, Go Sugiarto, Vireak Thon, Joel Hwang, Li Ding, Liana Hie, Xi Chen

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Heparan sulfate analogues: Highly efficient one-pot multienzyme (OPME) chemoenzymatic systems for the activation and transfer of N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA) have been developed. They were applied to the sequential tailored synthesis of N-sulfated analogues of heparan sulfate oligosaccharides, which could be potential therapeutics.

Original languageEnglish (US)
Pages (from-to)11852-11856
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number45
DOIs
StatePublished - Nov 4 2013

Keywords

  • carbohydrates
  • chemoenzymatic systems
  • enzymes
  • heparin
  • structure-activity relationships

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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