Tailored design and synthesis of heparan sulfate oligosaccharide analogues using sequential one-pot multienzyme systems

Yi Chen, Yanhong Li, Hai Yu, Go Sugiarto, Vireak Thon, Joel Hwang, Li Ding, Liana Hie, Xi Chen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Heparan sulfate analogues: Highly efficient one-pot multienzyme (OPME) chemoenzymatic systems for the activation and transfer of N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA) have been developed. They were applied to the sequential tailored synthesis of N-sulfated analogues of heparan sulfate oligosaccharides, which could be potential therapeutics.

Original languageEnglish (US)
Pages (from-to)11852-11856
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number45
DOIs
StatePublished - Nov 4 2013

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Oligosaccharides
Heparitin Sulfate
Glucuronic Acid
Acetylglucosamine
Chemical activation
Acids
Sulfates

Keywords

  • carbohydrates
  • chemoenzymatic systems
  • enzymes
  • heparin
  • structure-activity relationships

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Tailored design and synthesis of heparan sulfate oligosaccharide analogues using sequential one-pot multienzyme systems. / Chen, Yi; Li, Yanhong; Yu, Hai; Sugiarto, Go; Thon, Vireak; Hwang, Joel; Ding, Li; Hie, Liana; Chen, Xi.

In: Angewandte Chemie - International Edition, Vol. 52, No. 45, 04.11.2013, p. 11852-11856.

Research output: Contribution to journalArticle

Chen, Yi ; Li, Yanhong ; Yu, Hai ; Sugiarto, Go ; Thon, Vireak ; Hwang, Joel ; Ding, Li ; Hie, Liana ; Chen, Xi. / Tailored design and synthesis of heparan sulfate oligosaccharide analogues using sequential one-pot multienzyme systems. In: Angewandte Chemie - International Edition. 2013 ; Vol. 52, No. 45. pp. 11852-11856.
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