Heparan sulfate analogues: Highly efficient one-pot multienzyme (OPME) chemoenzymatic systems for the activation and transfer of N-acetylglucosamine (GlcNAc) and glucuronic acid (GlcA) have been developed. They were applied to the sequential tailored synthesis of N-sulfated analogues of heparan sulfate oligosaccharides, which could be potential therapeutics.
- chemoenzymatic systems
- structure-activity relationships
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