Tacrolimus enhances the recovery of normal laryngeal muscle fibre distribution after reinnervation

P. Gorphe, N. Guerout, M. Birchall, G. Terenghi, J. P. Marie

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: To assess the recovery of various muscle fibre types in the posterior cricoarytenoid muscle after laryngeal reinnervation in the rat, and to determine the influence of tacrolimus on this process. Methods: Four groups of rats underwent resection and anastomosis of the left vagus nerve, and were administered either tacrolimus at a low dose or an immunosuppressive dose, or cyclosporin A at a low dose or an immunosuppressive dose. A fifth group received surgery alone, and a sixth group received neither surgery nor drug treatment (healthy group). Muscles were removed for immunohistochemical analysis 45 days after surgery. Results: There was no difference in the proportion of types 1, 2a and 2b muscle fibres, comparing the immunosuppressive tacrolimus group and the healthy group, whereas there were fewer type 1 fibres in the group receiving surgery alone, compared with the healthy group (7 vs 12.1 per cent, respectively; p=0.0303). Conclusion: Tacrolimus enhanced the recovery of normal laryngeal muscle fibres after reinnervation in the rat, indicating a possible role in laryngeal transplantation.

Original languageEnglish (US)
Pages (from-to)1155-1158
Number of pages4
JournalJournal of Laryngology and Otology
Volume126
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

Fingerprint

Laryngeal Muscles
Tacrolimus
Immunosuppressive Agents
Muscles
Vagus Nerve
Ambulatory Surgical Procedures
Cyclosporine
Transplantation
Pharmaceutical Preparations

Keywords

  • Calcineurin Inhibitors
  • Laryngeal Reinnervation
  • Muscle Fibers
  • Tacrolimus

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Tacrolimus enhances the recovery of normal laryngeal muscle fibre distribution after reinnervation. / Gorphe, P.; Guerout, N.; Birchall, M.; Terenghi, G.; Marie, J. P.

In: Journal of Laryngology and Otology, Vol. 126, No. 11, 11.2012, p. 1155-1158.

Research output: Contribution to journalArticle

Gorphe, P. ; Guerout, N. ; Birchall, M. ; Terenghi, G. ; Marie, J. P. / Tacrolimus enhances the recovery of normal laryngeal muscle fibre distribution after reinnervation. In: Journal of Laryngology and Otology. 2012 ; Vol. 126, No. 11. pp. 1155-1158.
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