T2 relaxation time measurements are limited in monitoring progression, once advanced cartilage defects at the knee occur: Longitudinal data from the osteoarthritis initiative

Pia M. Jungmann, Mareen S. Kraus, Lorenzo Nardo, Hans Liebl, Hamza Alizai, Gabby B. Joseph, Felix Liu, John Lynch, Chuck E. McCulloch, Michael C. Nevitt, Thomas M. Link

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Purpose: To study the natural evolution of cartilage T2 relaxation times in knees with various extents of morphological cartilage abnormalities, assessed with 3 Tesla MRI from the Osteoarthritis Initiative. Materials and Methods: Right knee MRIs of 245, 45- to 60-year-old individuals without radiographic osteoarthritis (OA) were included. Cartilage was segmented and T2 maps were generated in five compartments (patella, medial and lateral femoral condyle, medial, and lateral tibia) at baseline and 2-year follow-up. We examined the association of T2 values and 2-year change of T2 values with various Whole-Organ MR Imaging Scores (WORMS). Statistical analysis was performed with analysis of variance and Students t-tests. Results: Higher baseline T2 was associated with more severe cartilage defects at baseline and subsequent cartilage loss (P < 0.001). However, longitudinal T2 change was inversely associated with both baseline (P = 0.038) and follow-up (P = 0.002) severity of cartilage defects. Knees that developed new cartilage defects had smaller increases in T 2 than subjects without defects (P = 0.045). Individuals with higher baseline T2 showed smaller T2 increases over time (P < 0.001). Conclusion: An inverse correlation of longitudinal T2 changes versus baseline T2 values and morphological cartilage abnormalities suggests that once morphological cartilage defects occur, T2 values may be limited for evaluating further cartilage degradation.

Original languageEnglish (US)
Pages (from-to)1415-1424
Number of pages10
JournalJournal of Magnetic Resonance Imaging
Volume38
Issue number6
DOIs
StatePublished - Dec 1 2013
Externally publishedYes

Fingerprint

Osteoarthritis
Cartilage
Knee
Patella
Thigh
Tibia
Analysis of Variance
Students
Bone and Bones

Keywords

  • cartilage
  • longitudinal analysis
  • MRI
  • osteoarthritis
  • T progression
  • WORMS

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

T2 relaxation time measurements are limited in monitoring progression, once advanced cartilage defects at the knee occur : Longitudinal data from the osteoarthritis initiative. / Jungmann, Pia M.; Kraus, Mareen S.; Nardo, Lorenzo; Liebl, Hans; Alizai, Hamza; Joseph, Gabby B.; Liu, Felix; Lynch, John; McCulloch, Chuck E.; Nevitt, Michael C.; Link, Thomas M.

In: Journal of Magnetic Resonance Imaging, Vol. 38, No. 6, 01.12.2013, p. 1415-1424.

Research output: Contribution to journalArticle

Jungmann, Pia M. ; Kraus, Mareen S. ; Nardo, Lorenzo ; Liebl, Hans ; Alizai, Hamza ; Joseph, Gabby B. ; Liu, Felix ; Lynch, John ; McCulloch, Chuck E. ; Nevitt, Michael C. ; Link, Thomas M. / T2 relaxation time measurements are limited in monitoring progression, once advanced cartilage defects at the knee occur : Longitudinal data from the osteoarthritis initiative. In: Journal of Magnetic Resonance Imaging. 2013 ; Vol. 38, No. 6. pp. 1415-1424.
@article{ead20212243b4aa8a6883caa5a2a597b,
title = "T2 relaxation time measurements are limited in monitoring progression, once advanced cartilage defects at the knee occur: Longitudinal data from the osteoarthritis initiative",
abstract = "Purpose: To study the natural evolution of cartilage T2 relaxation times in knees with various extents of morphological cartilage abnormalities, assessed with 3 Tesla MRI from the Osteoarthritis Initiative. Materials and Methods: Right knee MRIs of 245, 45- to 60-year-old individuals without radiographic osteoarthritis (OA) were included. Cartilage was segmented and T2 maps were generated in five compartments (patella, medial and lateral femoral condyle, medial, and lateral tibia) at baseline and 2-year follow-up. We examined the association of T2 values and 2-year change of T2 values with various Whole-Organ MR Imaging Scores (WORMS). Statistical analysis was performed with analysis of variance and Students t-tests. Results: Higher baseline T2 was associated with more severe cartilage defects at baseline and subsequent cartilage loss (P < 0.001). However, longitudinal T2 change was inversely associated with both baseline (P = 0.038) and follow-up (P = 0.002) severity of cartilage defects. Knees that developed new cartilage defects had smaller increases in T 2 than subjects without defects (P = 0.045). Individuals with higher baseline T2 showed smaller T2 increases over time (P < 0.001). Conclusion: An inverse correlation of longitudinal T2 changes versus baseline T2 values and morphological cartilage abnormalities suggests that once morphological cartilage defects occur, T2 values may be limited for evaluating further cartilage degradation.",
keywords = "cartilage, longitudinal analysis, MRI, osteoarthritis, T progression, WORMS",
author = "Jungmann, {Pia M.} and Kraus, {Mareen S.} and Lorenzo Nardo and Hans Liebl and Hamza Alizai and Joseph, {Gabby B.} and Felix Liu and John Lynch and McCulloch, {Chuck E.} and Nevitt, {Michael C.} and Link, {Thomas M.}",
year = "2013",
month = "12",
day = "1",
doi = "10.1002/jmri.24137",
language = "English (US)",
volume = "38",
pages = "1415--1424",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - T2 relaxation time measurements are limited in monitoring progression, once advanced cartilage defects at the knee occur

T2 - Longitudinal data from the osteoarthritis initiative

AU - Jungmann, Pia M.

AU - Kraus, Mareen S.

AU - Nardo, Lorenzo

AU - Liebl, Hans

AU - Alizai, Hamza

AU - Joseph, Gabby B.

AU - Liu, Felix

AU - Lynch, John

AU - McCulloch, Chuck E.

AU - Nevitt, Michael C.

AU - Link, Thomas M.

PY - 2013/12/1

Y1 - 2013/12/1

N2 - Purpose: To study the natural evolution of cartilage T2 relaxation times in knees with various extents of morphological cartilage abnormalities, assessed with 3 Tesla MRI from the Osteoarthritis Initiative. Materials and Methods: Right knee MRIs of 245, 45- to 60-year-old individuals without radiographic osteoarthritis (OA) were included. Cartilage was segmented and T2 maps were generated in five compartments (patella, medial and lateral femoral condyle, medial, and lateral tibia) at baseline and 2-year follow-up. We examined the association of T2 values and 2-year change of T2 values with various Whole-Organ MR Imaging Scores (WORMS). Statistical analysis was performed with analysis of variance and Students t-tests. Results: Higher baseline T2 was associated with more severe cartilage defects at baseline and subsequent cartilage loss (P < 0.001). However, longitudinal T2 change was inversely associated with both baseline (P = 0.038) and follow-up (P = 0.002) severity of cartilage defects. Knees that developed new cartilage defects had smaller increases in T 2 than subjects without defects (P = 0.045). Individuals with higher baseline T2 showed smaller T2 increases over time (P < 0.001). Conclusion: An inverse correlation of longitudinal T2 changes versus baseline T2 values and morphological cartilage abnormalities suggests that once morphological cartilage defects occur, T2 values may be limited for evaluating further cartilage degradation.

AB - Purpose: To study the natural evolution of cartilage T2 relaxation times in knees with various extents of morphological cartilage abnormalities, assessed with 3 Tesla MRI from the Osteoarthritis Initiative. Materials and Methods: Right knee MRIs of 245, 45- to 60-year-old individuals without radiographic osteoarthritis (OA) were included. Cartilage was segmented and T2 maps were generated in five compartments (patella, medial and lateral femoral condyle, medial, and lateral tibia) at baseline and 2-year follow-up. We examined the association of T2 values and 2-year change of T2 values with various Whole-Organ MR Imaging Scores (WORMS). Statistical analysis was performed with analysis of variance and Students t-tests. Results: Higher baseline T2 was associated with more severe cartilage defects at baseline and subsequent cartilage loss (P < 0.001). However, longitudinal T2 change was inversely associated with both baseline (P = 0.038) and follow-up (P = 0.002) severity of cartilage defects. Knees that developed new cartilage defects had smaller increases in T 2 than subjects without defects (P = 0.045). Individuals with higher baseline T2 showed smaller T2 increases over time (P < 0.001). Conclusion: An inverse correlation of longitudinal T2 changes versus baseline T2 values and morphological cartilage abnormalities suggests that once morphological cartilage defects occur, T2 values may be limited for evaluating further cartilage degradation.

KW - cartilage

KW - longitudinal analysis

KW - MRI

KW - osteoarthritis

KW - T progression

KW - WORMS

UR - http://www.scopus.com/inward/record.url?scp=84890120022&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84890120022&partnerID=8YFLogxK

U2 - 10.1002/jmri.24137

DO - 10.1002/jmri.24137

M3 - Article

C2 - 24038491

AN - SCOPUS:84890120022

VL - 38

SP - 1415

EP - 1424

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 6

ER -