T1ρ and T2 relaxation times are associated with progression of hip osteoarthritis

M. C. Gallo, C. Wyatt, V. Pedoia, D. Kumar, S. Lee, Lorenzo Nardo, T. M. Link, R. B. Souza, S. Majumdar

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Objective To evaluate whether baseline T and T2 relaxation times of hip cartilage are associated with magnetic resonance imaging (MRI) based progression of hip osteoarthritis (OA) at 18 months. Methods 3T MRI studies of the hip were obtained at baseline and 18-month follow-up for 54 subjects without evidence of severe OA at baseline [Kellgren–Lawrence (KL) score of 0–3]. 2D fast spin-echo sequences were used for semi-quantitative morphological scoring of cartilage lesions and a combined T/T2 sequence was used to quantitatively assess cartilage composition. Progression of hip OA was defined based on incident or progression of morphological semi-quantitative grade at 18 months. Baseline T and T2 relaxation times were compared between progressors and non-progressors using one-way analysis of variance and Mann–Whitney U tests and used to predict progression with binary logistic regression after adjusting for age, gender, body mass index, and KL score. Additionally, a novel voxel-based relaxometry technique was used to compare the spatial distribution of baseline T and T2 between progressors and non-progressors. Results Significantly higher baseline T and T2 values were observed in hip OA progressors compared to non-progressors, particularly in the posterosuperior and anterior aspects of the femoral cartilage. Logistic regression showed that higher baseline T or T2 values in the femoral cartilage were significantly associated with progression of femoral cartilage lesions at 18 months. Conclusion T and T2 relaxation parameters are associated with morphological cartilage degeneration at 18 months and may serve as potential imaging biomarkers for progression of cartilage lesions in hip OA.

Original languageEnglish (US)
Pages (from-to)1399-1407
Number of pages9
JournalOsteoarthritis and Cartilage
Volume24
Issue number8
DOIs
StatePublished - Aug 1 2016
Externally publishedYes

Fingerprint

Hip Osteoarthritis
Cartilage
Relaxation time
Thigh
Magnetic resonance
Imaging techniques
Logistics
Hip
Logistic Models
Magnetic Resonance Imaging
Biomarkers
Analysis of variance (ANOVA)
Osteoarthritis
Spatial distribution
Analysis of Variance
Body Mass Index
Chemical analysis

Keywords

  • Hip
  • Magnetic resonance imaging
  • Osteoarthritis
  • Progression
  • T/T
  • Voxel-based relaxometry

ASJC Scopus subject areas

  • Rheumatology
  • Biomedical Engineering
  • Orthopedics and Sports Medicine

Cite this

T1ρ and T2 relaxation times are associated with progression of hip osteoarthritis. / Gallo, M. C.; Wyatt, C.; Pedoia, V.; Kumar, D.; Lee, S.; Nardo, Lorenzo; Link, T. M.; Souza, R. B.; Majumdar, S.

In: Osteoarthritis and Cartilage, Vol. 24, No. 8, 01.08.2016, p. 1399-1407.

Research output: Contribution to journalArticle

Gallo, MC, Wyatt, C, Pedoia, V, Kumar, D, Lee, S, Nardo, L, Link, TM, Souza, RB & Majumdar, S 2016, 'T1ρ and T2 relaxation times are associated with progression of hip osteoarthritis', Osteoarthritis and Cartilage, vol. 24, no. 8, pp. 1399-1407. https://doi.org/10.1016/j.joca.2016.03.005
Gallo, M. C. ; Wyatt, C. ; Pedoia, V. ; Kumar, D. ; Lee, S. ; Nardo, Lorenzo ; Link, T. M. ; Souza, R. B. ; Majumdar, S. / T1ρ and T2 relaxation times are associated with progression of hip osteoarthritis. In: Osteoarthritis and Cartilage. 2016 ; Vol. 24, No. 8. pp. 1399-1407.
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abstract = "Objective To evaluate whether baseline T1ρ and T2 relaxation times of hip cartilage are associated with magnetic resonance imaging (MRI) based progression of hip osteoarthritis (OA) at 18 months. Methods 3T MRI studies of the hip were obtained at baseline and 18-month follow-up for 54 subjects without evidence of severe OA at baseline [Kellgren–Lawrence (KL) score of 0–3]. 2D fast spin-echo sequences were used for semi-quantitative morphological scoring of cartilage lesions and a combined T1ρ/T2 sequence was used to quantitatively assess cartilage composition. Progression of hip OA was defined based on incident or progression of morphological semi-quantitative grade at 18 months. Baseline T1ρ and T2 relaxation times were compared between progressors and non-progressors using one-way analysis of variance and Mann–Whitney U tests and used to predict progression with binary logistic regression after adjusting for age, gender, body mass index, and KL score. Additionally, a novel voxel-based relaxometry technique was used to compare the spatial distribution of baseline T1ρ and T2 between progressors and non-progressors. Results Significantly higher baseline T1ρ and T2 values were observed in hip OA progressors compared to non-progressors, particularly in the posterosuperior and anterior aspects of the femoral cartilage. Logistic regression showed that higher baseline T1ρ or T2 values in the femoral cartilage were significantly associated with progression of femoral cartilage lesions at 18 months. Conclusion T1ρ and T2 relaxation parameters are associated with morphological cartilage degeneration at 18 months and may serve as potential imaging biomarkers for progression of cartilage lesions in hip OA.",
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AU - Gallo, M. C.

AU - Wyatt, C.

AU - Pedoia, V.

AU - Kumar, D.

AU - Lee, S.

AU - Nardo, Lorenzo

AU - Link, T. M.

AU - Souza, R. B.

AU - Majumdar, S.

PY - 2016/8/1

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N2 - Objective To evaluate whether baseline T1ρ and T2 relaxation times of hip cartilage are associated with magnetic resonance imaging (MRI) based progression of hip osteoarthritis (OA) at 18 months. Methods 3T MRI studies of the hip were obtained at baseline and 18-month follow-up for 54 subjects without evidence of severe OA at baseline [Kellgren–Lawrence (KL) score of 0–3]. 2D fast spin-echo sequences were used for semi-quantitative morphological scoring of cartilage lesions and a combined T1ρ/T2 sequence was used to quantitatively assess cartilage composition. Progression of hip OA was defined based on incident or progression of morphological semi-quantitative grade at 18 months. Baseline T1ρ and T2 relaxation times were compared between progressors and non-progressors using one-way analysis of variance and Mann–Whitney U tests and used to predict progression with binary logistic regression after adjusting for age, gender, body mass index, and KL score. Additionally, a novel voxel-based relaxometry technique was used to compare the spatial distribution of baseline T1ρ and T2 between progressors and non-progressors. Results Significantly higher baseline T1ρ and T2 values were observed in hip OA progressors compared to non-progressors, particularly in the posterosuperior and anterior aspects of the femoral cartilage. Logistic regression showed that higher baseline T1ρ or T2 values in the femoral cartilage were significantly associated with progression of femoral cartilage lesions at 18 months. Conclusion T1ρ and T2 relaxation parameters are associated with morphological cartilage degeneration at 18 months and may serve as potential imaging biomarkers for progression of cartilage lesions in hip OA.

AB - Objective To evaluate whether baseline T1ρ and T2 relaxation times of hip cartilage are associated with magnetic resonance imaging (MRI) based progression of hip osteoarthritis (OA) at 18 months. Methods 3T MRI studies of the hip were obtained at baseline and 18-month follow-up for 54 subjects without evidence of severe OA at baseline [Kellgren–Lawrence (KL) score of 0–3]. 2D fast spin-echo sequences were used for semi-quantitative morphological scoring of cartilage lesions and a combined T1ρ/T2 sequence was used to quantitatively assess cartilage composition. Progression of hip OA was defined based on incident or progression of morphological semi-quantitative grade at 18 months. Baseline T1ρ and T2 relaxation times were compared between progressors and non-progressors using one-way analysis of variance and Mann–Whitney U tests and used to predict progression with binary logistic regression after adjusting for age, gender, body mass index, and KL score. Additionally, a novel voxel-based relaxometry technique was used to compare the spatial distribution of baseline T1ρ and T2 between progressors and non-progressors. Results Significantly higher baseline T1ρ and T2 values were observed in hip OA progressors compared to non-progressors, particularly in the posterosuperior and anterior aspects of the femoral cartilage. Logistic regression showed that higher baseline T1ρ or T2 values in the femoral cartilage were significantly associated with progression of femoral cartilage lesions at 18 months. Conclusion T1ρ and T2 relaxation parameters are associated with morphological cartilage degeneration at 18 months and may serve as potential imaging biomarkers for progression of cartilage lesions in hip OA.

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