T cells in the female reproductive tract can both block and facilitate HIV transmission

Chris J Miller, Ronald S. Veazey

Research output: Contribution to journalReview article

Abstract

Because HIV is sexually transmitted, there is considerable interest in defining the nature of anti-HIV immunity in the Female Reproductive Tract (FRT) and in developing ways to elicit antiviral immunity in the FRT through vaccination. Although it is assumed that the mucosal immune system of the FRT is of central importance for protection against sexually transmitted diseases, including HIV, this arm of the immune system has only recently been studied. Here, we provide a brief review of the role of T cells in the FRT in blocking and facilitating HIV transmission.

Original languageEnglish (US)
Pages (from-to)36-40
Number of pages5
JournalCurrent Immunology Reviews
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2019

Keywords

  • Cervix
  • Hiv
  • Sexually transmitted disease
  • T cell
  • Vagina
  • Viral infections

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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