Abstract
The bronchial inflammation characterising asthma represents a specialised form of cell-mediated immune reactions, in which products of activated CD4+ T cells orchestrate the accumulation and activation of granulocytes, particularly eosinophils. Through their toxic granule proteins, membrane derived lipid mediators and proinflammatory cytokines, eosinophils are suggested to be responsible for the changes in airway submucosal tissue resulting in altered airway responsiveness. T cell activation is followed by the synthesis and release of cytokines of which IL-3, IL-5 and GM-CSF are particularly important in the site-specific accumulation, prolonged survival and activation of eosinophils. This review focuses on the interaction of these two cell types with particular interest in the cytokines which may be responsible for the development of eosinophilic airway inflammation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 19-29 |
| Number of pages | 11 |
| Journal | Acta Microbiologica et Immunologica Hungarica |
| Volume | 45 |
| Issue number | 1 |
| State | Published - 1998 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology and Microbiology(all)
- Microbiology
- Medicine(all)
Cite this
T cells and eosinophils in asthma. / Haczku, Angela Franciska.
In: Acta Microbiologica et Immunologica Hungarica, Vol. 45, No. 1, 1998, p. 19-29.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - T cells and eosinophils in asthma
AU - Haczku, Angela Franciska
PY - 1998
Y1 - 1998
N2 - The bronchial inflammation characterising asthma represents a specialised form of cell-mediated immune reactions, in which products of activated CD4+ T cells orchestrate the accumulation and activation of granulocytes, particularly eosinophils. Through their toxic granule proteins, membrane derived lipid mediators and proinflammatory cytokines, eosinophils are suggested to be responsible for the changes in airway submucosal tissue resulting in altered airway responsiveness. T cell activation is followed by the synthesis and release of cytokines of which IL-3, IL-5 and GM-CSF are particularly important in the site-specific accumulation, prolonged survival and activation of eosinophils. This review focuses on the interaction of these two cell types with particular interest in the cytokines which may be responsible for the development of eosinophilic airway inflammation.
AB - The bronchial inflammation characterising asthma represents a specialised form of cell-mediated immune reactions, in which products of activated CD4+ T cells orchestrate the accumulation and activation of granulocytes, particularly eosinophils. Through their toxic granule proteins, membrane derived lipid mediators and proinflammatory cytokines, eosinophils are suggested to be responsible for the changes in airway submucosal tissue resulting in altered airway responsiveness. T cell activation is followed by the synthesis and release of cytokines of which IL-3, IL-5 and GM-CSF are particularly important in the site-specific accumulation, prolonged survival and activation of eosinophils. This review focuses on the interaction of these two cell types with particular interest in the cytokines which may be responsible for the development of eosinophilic airway inflammation.
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M3 - Article
C2 - 9595149
AN - SCOPUS:0031626811
VL - 45
SP - 19
EP - 29
JO - Acta Microbiologica et Immunologica Hungarica
JF - Acta Microbiologica et Immunologica Hungarica
SN - 1217-8950
IS - 1
ER -