T cell receptor-γ/δ cells protect mice from herpes simplex virus type 1-induced lethal encephalitis

Roger Sciammas, P. Kodukula, Q. Tang, R. L. Hendricks, J. A. Bluestone

Research output: Contribution to journalArticle

143 Citations (Scopus)

Abstract

Increased numbers of T cell receptor (TCR)-γ/δ cells have been observed in animal models of influenza and sendai virus refections, as well as in patients infected with human immunodeficiency virus and herpes simplex virus type 1 (HSV-1). However, a direct role for TCR-γ/δ cells in protective immunity for pathogenic vital refection has not been demonstrated. To define the role of TCR-γ/δ cells in anti-HSV-1 immunity, TCR-α(-/-) mice treated with anti-TCR-γ/δ monoclonal antibodies or TCR-γ/δ x TCR- α/β double-deficient mice were infected with HSV-1 by footpad or ocular routes of infection. In both models of HSV-1 infection, TCR-γ/δ cells limited severe HSV-1-induced epithelial lesions and greatly reduced mortality by preventing the development of lethal viral encephalitis. The observed protection resulted from TCR-γ/δ cell-mediated arrest of both viral replication and neurovirulence. The demonstration that TCR-γ/δ cells play an important protective role in murine HSV-1 infections supports their potential contribution to the immune responses in human HSV-1 refection. Thus, this study demonstrates that TCR-γ/δ cells may play an important regulatory role in human HSV-1 infections.

Original languageEnglish (US)
Pages (from-to)1969-1975
Number of pages7
JournalJournal of Experimental Medicine
Volume185
Issue number11
DOIs
StatePublished - Jun 2 1997
Externally publishedYes

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Human Herpesvirus 1
Encephalitis
T-Cell Antigen Receptor
Virus Diseases
Immunity
Viral Encephalitis
Eye Infections
Sendai virus
Orthomyxoviridae
Animal Models
Monoclonal Antibodies
HIV

ASJC Scopus subject areas

  • Immunology

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T cell receptor-γ/δ cells protect mice from herpes simplex virus type 1-induced lethal encephalitis. / Sciammas, Roger; Kodukula, P.; Tang, Q.; Hendricks, R. L.; Bluestone, J. A.

In: Journal of Experimental Medicine, Vol. 185, No. 11, 02.06.1997, p. 1969-1975.

Research output: Contribution to journalArticle

Sciammas, Roger ; Kodukula, P. ; Tang, Q. ; Hendricks, R. L. ; Bluestone, J. A. / T cell receptor-γ/δ cells protect mice from herpes simplex virus type 1-induced lethal encephalitis. In: Journal of Experimental Medicine. 1997 ; Vol. 185, No. 11. pp. 1969-1975.
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