T cell immunity in hepatitis B and hepatitis C virus infection: Implications for autoimmunity

Yasunori Ichiki, Xiaosong He, Shinji Shimoda, Hiromi Ishibashi, Emmet B. Keeffe, Lorenzo Rossaro, M. Eric Gershwin

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

T cells are involved in the pathogenesis of important liver diseases including both autoimmune liver diseases and viral hepatitis. In addition to playing a crucial role in the control of hepatitis viruses, T cell responses are also responsible for the liver injury during acute and chronic phases of viral hepatitis. In this article, we reviewed current literature on T cell immunity to hepatitis B and C viruses. In addition, antigen presenting cells that are critical for T cell immunity against these viruses are also discussed. This will provide insights to the understanding of T cell immunity in autoimmune liver diseases due to the similar role of T cells in autoimmune liver diseases and viral hepatitis.

Original languageEnglish (US)
Pages (from-to)82-95
Number of pages14
JournalAutoimmunity Reviews
Volume4
Issue number2
DOIs
StatePublished - Feb 2005

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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