T cell immunity and primary biliary cirrhosis

Hiromi Ishibashi, Minoru Nakamura, Shinji Shimoda, M. Eric Gershwin

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

T lymphocytes play a pivotal role in the autoimmune response in primary biliary cirrhosis (PBC). Recent studies have shown that there is overlapping in the PDC-E2-specific T and B cell epitopes. In addition, helper T and cytotoxic T cell epitopes all contain a shared peptide sequence. In addition, recognition of exogenous antigens including bacterial antigens by autoantigen-specific T cell and the mechanism of molecular mimicry provide a clue to clarifying the pathogenesis of PBC. Furthermore, the findings that autoantigen-immune complexes cross present and also that the presentation of autoantigen is of a higher relative efficiency, define a unique role of autoantibodies in the pathogenesis of the autoimmune disease. The mechanism of immune-mediated bile duct damage in PBC, including the possible role of T cell-mediated cytotoxicity and molecular mimicry is discussed.

Original languageEnglish (US)
Pages (from-to)19-24
Number of pages6
JournalAutoimmunity Reviews
Volume2
Issue number1
DOIs
StatePublished - Jan 2003

Keywords

  • 2-Oxo acid dehydrogenase complex
  • Antimitochondrial antibodies
  • Autoimmunity
  • Molecular mimicry
  • Primary biliary cirrhosis
  • T cell immunity

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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