TY - JOUR
T1 - T Cell Factor 1 Is Required for Group 2 Innate Lymphoid Cell Generation
AU - Yang, Qi
AU - Monticelli, Laurel A.
AU - Saenz, Steven A.
AU - Chi, Anthony Wei Shine
AU - Sonnenberg, Gregory F.
AU - Tang, Jiangbo
AU - De Obaldia, Maria Elena
AU - Bailis, Will
AU - Bryson, Jerrod L.
AU - Toscano, Kristin
AU - Huang, Jian
AU - Haczku, Angela Franciska
AU - Pear, Warren S.
AU - Artis, David
AU - Bhandoola, Avinash
PY - 2013/4/18
Y1 - 2013/4/18
N2 - Group 2 innate lymphoid cells (ILC2) are innate lymphocytes that confer protective type 2 immunity during helminth infection and are also involved in allergic airway inflammation. Here we report that ILC2 development required T cell factor 1 (TCF-1, the product of the Tcf7 gene), a transcription factor also implicated in T cell lineage specification. Tcf7-/- mice lack ILC2, and were unable to mount ILC2-mediated innate type 2 immune responses. Forced expression of TCF-1 in bone marrow progenitors partially bypassed the requirement for Notch signaling in the generation of ILC2 in vivo. TCF-1 acted through both GATA-3-dependent and GATA-3-independent pathways to promote the generation of ILC2. These results are reminiscent of the critical roles of TCF-1 in early T cell development. Hence, transcription factors that underlie early steps of T cell development are also implicated in the development of innate lymphoid cells.
AB - Group 2 innate lymphoid cells (ILC2) are innate lymphocytes that confer protective type 2 immunity during helminth infection and are also involved in allergic airway inflammation. Here we report that ILC2 development required T cell factor 1 (TCF-1, the product of the Tcf7 gene), a transcription factor also implicated in T cell lineage specification. Tcf7-/- mice lack ILC2, and were unable to mount ILC2-mediated innate type 2 immune responses. Forced expression of TCF-1 in bone marrow progenitors partially bypassed the requirement for Notch signaling in the generation of ILC2 in vivo. TCF-1 acted through both GATA-3-dependent and GATA-3-independent pathways to promote the generation of ILC2. These results are reminiscent of the critical roles of TCF-1 in early T cell development. Hence, transcription factors that underlie early steps of T cell development are also implicated in the development of innate lymphoid cells.
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U2 - 10.1016/j.immuni.2012.12.003
DO - 10.1016/j.immuni.2012.12.003
M3 - Article
C2 - 23601684
AN - SCOPUS:84876762753
VL - 38
SP - 694
EP - 704
JO - Immunity
JF - Immunity
SN - 1074-7613
IS - 4
ER -