T Cell Factor 1 Is Required for Group 2 Innate Lymphoid Cell Generation

Qi Yang, Laurel A. Monticelli, Steven A. Saenz, Anthony Wei Shine Chi, Gregory F. Sonnenberg, Jiangbo Tang, Maria Elena De Obaldia, Will Bailis, Jerrod L. Bryson, Kristin Toscano, Jian Huang, Angela Franciska Haczku, Warren S. Pear, David Artis, Avinash Bhandoola

Research output: Contribution to journalArticlepeer-review

178 Scopus citations


Group 2 innate lymphoid cells (ILC2) are innate lymphocytes that confer protective type 2 immunity during helminth infection and are also involved in allergic airway inflammation. Here we report that ILC2 development required T cell factor 1 (TCF-1, the product of the Tcf7 gene), a transcription factor also implicated in T cell lineage specification. Tcf7-/- mice lack ILC2, and were unable to mount ILC2-mediated innate type 2 immune responses. Forced expression of TCF-1 in bone marrow progenitors partially bypassed the requirement for Notch signaling in the generation of ILC2 in vivo. TCF-1 acted through both GATA-3-dependent and GATA-3-independent pathways to promote the generation of ILC2. These results are reminiscent of the critical roles of TCF-1 in early T cell development. Hence, transcription factors that underlie early steps of T cell development are also implicated in the development of innate lymphoid cells.

Original languageEnglish (US)
Pages (from-to)694-704
Number of pages11
Issue number4
StatePublished - Apr 18 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases
  • Immunology


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