Abstract
Group 2 innate lymphoid cells (ILC2) are innate lymphocytes that confer protective type 2 immunity during helminth infection and are also involved in allergic airway inflammation. Here we report that ILC2 development required T cell factor 1 (TCF-1, the product of the Tcf7 gene), a transcription factor also implicated in T cell lineage specification. Tcf7-/- mice lack ILC2, and were unable to mount ILC2-mediated innate type 2 immune responses. Forced expression of TCF-1 in bone marrow progenitors partially bypassed the requirement for Notch signaling in the generation of ILC2 in vivo. TCF-1 acted through both GATA-3-dependent and GATA-3-independent pathways to promote the generation of ILC2. These results are reminiscent of the critical roles of TCF-1 in early T cell development. Hence, transcription factors that underlie early steps of T cell development are also implicated in the development of innate lymphoid cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 694-704 |
| Number of pages | 11 |
| Journal | Immunity |
| Volume | 38 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 18 2013 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Immunology and Allergy
- Infectious Diseases
- Immunology
Cite this
T Cell Factor 1 Is Required for Group 2 Innate Lymphoid Cell Generation. / Yang, Qi; Monticelli, Laurel A.; Saenz, Steven A.; Chi, Anthony Wei Shine; Sonnenberg, Gregory F.; Tang, Jiangbo; De Obaldia, Maria Elena; Bailis, Will; Bryson, Jerrod L.; Toscano, Kristin; Huang, Jian; Haczku, Angela Franciska; Pear, Warren S.; Artis, David; Bhandoola, Avinash.
In: Immunity, Vol. 38, No. 4, 18.04.2013, p. 694-704.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - T Cell Factor 1 Is Required for Group 2 Innate Lymphoid Cell Generation
AU - Yang, Qi
AU - Monticelli, Laurel A.
AU - Saenz, Steven A.
AU - Chi, Anthony Wei Shine
AU - Sonnenberg, Gregory F.
AU - Tang, Jiangbo
AU - De Obaldia, Maria Elena
AU - Bailis, Will
AU - Bryson, Jerrod L.
AU - Toscano, Kristin
AU - Huang, Jian
AU - Haczku, Angela Franciska
AU - Pear, Warren S.
AU - Artis, David
AU - Bhandoola, Avinash
PY - 2013/4/18
Y1 - 2013/4/18
N2 - Group 2 innate lymphoid cells (ILC2) are innate lymphocytes that confer protective type 2 immunity during helminth infection and are also involved in allergic airway inflammation. Here we report that ILC2 development required T cell factor 1 (TCF-1, the product of the Tcf7 gene), a transcription factor also implicated in T cell lineage specification. Tcf7-/- mice lack ILC2, and were unable to mount ILC2-mediated innate type 2 immune responses. Forced expression of TCF-1 in bone marrow progenitors partially bypassed the requirement for Notch signaling in the generation of ILC2 in vivo. TCF-1 acted through both GATA-3-dependent and GATA-3-independent pathways to promote the generation of ILC2. These results are reminiscent of the critical roles of TCF-1 in early T cell development. Hence, transcription factors that underlie early steps of T cell development are also implicated in the development of innate lymphoid cells.
AB - Group 2 innate lymphoid cells (ILC2) are innate lymphocytes that confer protective type 2 immunity during helminth infection and are also involved in allergic airway inflammation. Here we report that ILC2 development required T cell factor 1 (TCF-1, the product of the Tcf7 gene), a transcription factor also implicated in T cell lineage specification. Tcf7-/- mice lack ILC2, and were unable to mount ILC2-mediated innate type 2 immune responses. Forced expression of TCF-1 in bone marrow progenitors partially bypassed the requirement for Notch signaling in the generation of ILC2 in vivo. TCF-1 acted through both GATA-3-dependent and GATA-3-independent pathways to promote the generation of ILC2. These results are reminiscent of the critical roles of TCF-1 in early T cell development. Hence, transcription factors that underlie early steps of T cell development are also implicated in the development of innate lymphoid cells.
UR - http://www.scopus.com/inward/record.url?scp=84876762753&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876762753&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2012.12.003
DO - 10.1016/j.immuni.2012.12.003
M3 - Article
C2 - 23601684
AN - SCOPUS:84876762753
VL - 38
SP - 694
EP - 704
JO - Immunity
JF - Immunity
SN - 1074-7613
IS - 4
ER -