T and B lymphocytes in patients with Down's syndrome

K. Reiser, Charles Whitcomb, K. Robinson, M. R. MacKenzie

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Individuals with Down's syndrome are thought to have abnormalities of immune function. Studies to quantify the number of peripheral blood T and B lymphocytes and serum immunoglobulins in 12 individuals and 12 sex and age matched control subjects were performed. Hepatitis B antigen and antithyroglobulin antibodies as markers of possible immune dysfunction were determined. The numbers of circulating T and B cells, and the level of serum immunoglobulins in children with Down's syndrome did not differ from non retarded control children. Circulating hepatitis B antigen and antithyroglobulin antibodies were not present. These studies indicated that quantitative abnormalities of T and B cells are not present in children with Down's syndrome. The data did not exclude the existence of qualitative abnormalities.

Original languageEnglish (US)
Pages (from-to)613-619
Number of pages7
JournalAmerican Journal of Mental Deficiency
Volume80
Issue number6
StatePublished - 1976

Fingerprint

Down Syndrome
Hepatitis B Antigens
Hepatitis B Antibodies
B-Lymphocytes
T-Lymphocytes
Immunoglobulins
Serum
Biomarkers
anti-thyroglobulin
Cells

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Reiser, K., Whitcomb, C., Robinson, K., & MacKenzie, M. R. (1976). T and B lymphocytes in patients with Down's syndrome. American Journal of Mental Deficiency, 80(6), 613-619.

T and B lymphocytes in patients with Down's syndrome. / Reiser, K.; Whitcomb, Charles; Robinson, K.; MacKenzie, M. R.

In: American Journal of Mental Deficiency, Vol. 80, No. 6, 1976, p. 613-619.

Research output: Contribution to journalArticle

Reiser, K, Whitcomb, C, Robinson, K & MacKenzie, MR 1976, 'T and B lymphocytes in patients with Down's syndrome', American Journal of Mental Deficiency, vol. 80, no. 6, pp. 613-619.
Reiser, K. ; Whitcomb, Charles ; Robinson, K. ; MacKenzie, M. R. / T and B lymphocytes in patients with Down's syndrome. In: American Journal of Mental Deficiency. 1976 ; Vol. 80, No. 6. pp. 613-619.
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