T and B lymphocytes in patients with Down's syndrome

K. Reiser, Charles Whitcomb, K. Robinson, M. R. MacKenzie

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Individuals with Down's syndrome are thought to have abnormalities of immune function. Studies to quantify the number of peripheral blood T and B lymphocytes and serum immunoglobulins in 12 individuals and 12 sex and age matched control subjects were performed. Hepatitis B antigen and antithyroglobulin antibodies as markers of possible immune dysfunction were determined. The numbers of circulating T and B cells, and the level of serum immunoglobulins in children with Down's syndrome did not differ from non retarded control children. Circulating hepatitis B antigen and antithyroglobulin antibodies were not present. These studies indicated that quantitative abnormalities of T and B cells are not present in children with Down's syndrome. The data did not exclude the existence of qualitative abnormalities.

Original languageEnglish (US)
Pages (from-to)613-619
Number of pages7
JournalAmerican Journal of Mental Deficiency
Issue number6
StatePublished - 1976

ASJC Scopus subject areas

  • Psychiatry and Mental health


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