Abstract
This work establishes a fluorescent live-cell reporter system to monitor local communication between malignant and non-malignant breast cancer cells. This system reveals that the EGFR-RAS-ERK signaling network amplifies small ligand fluctuations to generate dynamically heterogeneous gene expression states, which may provide an adaptive advantage for tumor cells.
Original language | English (US) |
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Pages (from-to) | 161-175.e5 |
Journal | Cell Systems |
Volume | 11 |
Issue number | 2 |
DOIs | |
State | Published - Aug 26 2020 |
Keywords
- basal-like breast cancer
- computational modeling
- EGFR
- ERK
- MAPK
- microenvironment
- plasticity
- RAS
- scRNA-seq
- systems biology
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Histology
- Cell Biology