Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity

Alexander E. Davies; Michael Pargett; Stefan Siebert; Taryn E. Gillies; Yongin Choi; Savannah J. Tobin; Abhineet R. Ram; Vaibhav Murthy; Celina Juliano; Gerald Quon; Mina J. Bissell; John G. Albeck

doi:10.1016/j.cels.2020.07.004

Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity

Alexander E. Davies, Michael Pargett, Stefan Siebert, Taryn E. Gillies, Yongin Choi, Savannah J. Tobin, Abhineet R. Ram, Vaibhav Murthy, Celina Juliano, Gerald Quon, Mina J. Bissell, John G. Albeck

Molecular and Cellular Biology

Research output: Contribution to journal › Article

Abstract

This work establishes a fluorescent live-cell reporter system to monitor local communication between malignant and non-malignant breast cancer cells. This system reveals that the EGFR-RAS-ERK signaling network amplifies small ligand fluctuations to generate dynamically heterogeneous gene expression states, which may provide an adaptive advantage for tumor cells.

Original language	English (US)
Pages (from-to)	161-175.e5
Journal	Cell Systems
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/j.cels.2020.07.004
State	Published - Aug 26 2020

Keywords

basal-like breast cancer
computational modeling
EGFR
ERK
MAPK
microenvironment
plasticity
RAS
scRNA-seq
systems biology

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology
Cell Biology

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Davies, A. E., Pargett, M., Siebert, S., Gillies, T. E., Choi, Y., Tobin, S. J., Ram, A. R., Murthy, V., Juliano, C., Quon, G., Bissell, M. J., & Albeck, J. G. (2020). Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity. Cell Systems, 11(2), 161-175.e5. https://doi.org/10.1016/j.cels.2020.07.004

Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity. / Davies, Alexander E.; Pargett, Michael; Siebert, Stefan; Gillies, Taryn E.; Choi, Yongin; Tobin, Savannah J.; Ram, Abhineet R.; Murthy, Vaibhav; Juliano, Celina; Quon, Gerald; Bissell, Mina J.; Albeck, John G.

In: Cell Systems, Vol. 11, No. 2, 26.08.2020, p. 161-175.e5.

Research output: Contribution to journal › Article

Davies, Alexander E. ; Pargett, Michael ; Siebert, Stefan ; Gillies, Taryn E. ; Choi, Yongin ; Tobin, Savannah J. ; Ram, Abhineet R. ; Murthy, Vaibhav ; Juliano, Celina ; Quon, Gerald ; Bissell, Mina J. ; Albeck, John G. / Systems-Level Properties of EGFR-RAS-ERK Signaling Amplify Local Signals to Generate Dynamic Gene Expression Heterogeneity. In: Cell Systems. 2020 ; Vol. 11, No. 2. pp. 161-175.e5.

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