Systems analysis of biological networks in skeletal muscle function

Lucas R. Smith, Gretchen Meyer, Richard L. Lieber

Research output: Contribution to journalReview article

28 Citations (Scopus)

Abstract

Skeletal muscle function depends on the efficient coordination among subcellular systems. These systems are composed of proteins encoded by a subset of genes, all of which are tightly regulated. In the cases where regulation is altered because of disease or injury, dysfunction occurs. To enable objective analysis of muscle gene expression profiles, we have defined nine biological networks whose coordination is critical to muscle function. We begin by describing the expression of proteins necessary for optimal neuromuscular junction function that results in the muscle cell action potential. That action potential is transmitted to proteins involved in excitation-contraction coupling enabling Ca2+ release. Ca2+ then activates contractile proteins supporting actin and myosin cross-bridge cycling. Force generated by cross-bridges is transmitted via cytoskeletal proteins through the sarcolemma and out to critical proteins that support the muscle extracellular matrix. Muscle contraction is fueled through many proteins that regulate energy metabolism. Inflammation is a common response to injury that can result in alteration of many pathways within muscle. Muscle also has multiple pathways that regulate size through atrophy or hypertrophy. Finally, the isoforms associated with fast muscle fibers and their corresponding isoforms in slow muscle fibers are delineated. These nine networks represent important biological systems that affect skeletal muscle function. Combining high-throughput systems analysis with advanced networking software will allow researchers to use these networks to objectively study skeletal muscle systems.

Original languageEnglish (US)
Pages (from-to)55-71
Number of pages17
JournalWiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume5
Issue number1
DOIs
StatePublished - Jan 1 2013
Externally publishedYes

Fingerprint

Systems Analysis
Muscle
Skeletal Muscle
Systems analysis
Muscles
Action Potentials
Protein Isoforms
Proteins
Contractile Proteins
Excitation Contraction Coupling
Sarcolemma
Cytoskeletal Proteins
Muscle Proteins
Neuromuscular Junction
Wounds and Injuries
Myosins
Muscle Contraction
Transcriptome
Muscle Cells
Hypertrophy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

Cite this

Systems analysis of biological networks in skeletal muscle function. / Smith, Lucas R.; Meyer, Gretchen; Lieber, Richard L.

In: Wiley Interdisciplinary Reviews: Systems Biology and Medicine, Vol. 5, No. 1, 01.01.2013, p. 55-71.

Research output: Contribution to journalReview article

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