Systemic mastocytosis in association with chronic lymphocytic leukemia and plasma cell myeloma

Shouying Du, Hooman Rashidi, Dzung T. Le, Thomas J. Kipps, H. Elizabeth Broome, Huan You Wang

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Systemic mastocytosis with associated clonal haematological non-mast cell lineage disease (SM-AHNMD) is a heterogeous group of mast cell disorders with different clinical, pathologic and underlying molecular characteristics. While myelomonocytic/myeloid neoplasia overwhelmingly predominates the AHNMD component, lymphoproliferative disorders rarely occur as an AHNMD component of SM-AHNMD. Here we report two cases of SM-AHNMD, in which the AHNMD component is chronic lymphocytic leukemia in one case, and concurrent chronic lymphocytic leukemia as well as plasma cell myeloma in another case. To the best of our knowledge, this is the first case report of SM-AHNMD with chronic lymphocytic leukemia and plasma cell dyscrasia simultaneously.

Original languageEnglish (US)
Pages (from-to)448-457
Number of pages10
JournalInternational Journal of Clinical and Experimental Pathology
Volume3
Issue number4
StatePublished - Sep 1 2010

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Keywords

  • Chronic lymphocytic leukemia
  • Systemic mastocytosis
  • Systemic mastocytosis with associated clonal haematological non-mast cell lineage disease

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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