Systemic focal epileptogenesis

M. P. Remler, W. H. Marcussen

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Rats that receive radiation to 0.25 cc of one cerebral hemisphere are clinically and electroencephalographically normal until there is a breakdown of the blood-brain barrier (BBB) at 3 to 6 months postradiation. This BBB lesion can be detected by transient focal seizure activity produced by the BBB-excluded systemic convulsant bicuculline methiodide. In two rats the seizure activity induced by this one injection was self-sustaining. In seven of 15 other rats tested, the subsequent administration of repeated 2 mg/kg injections created a chronic focus that continued to spike with great frequency for 3 weeks or more without further administration of any convulsant. In three of eight other rats, implanted minipumps delivering 180 μg/h of bicuculline methiodide produced self-sustaining epileptic activity.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalEpilepsia
Volume27
Issue number1
StatePublished - 1986

Fingerprint

Blood-Brain Barrier
Convulsants
Seizures
Injections
Cerebrum
Radiation
bicuculline methiodide

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Remler, M. P., & Marcussen, W. H. (1986). Systemic focal epileptogenesis. Epilepsia, 27(1), 35-42.

Systemic focal epileptogenesis. / Remler, M. P.; Marcussen, W. H.

In: Epilepsia, Vol. 27, No. 1, 1986, p. 35-42.

Research output: Contribution to journalArticle

Remler, MP & Marcussen, WH 1986, 'Systemic focal epileptogenesis', Epilepsia, vol. 27, no. 1, pp. 35-42.
Remler MP, Marcussen WH. Systemic focal epileptogenesis. Epilepsia. 1986;27(1):35-42.
Remler, M. P. ; Marcussen, W. H. / Systemic focal epileptogenesis. In: Epilepsia. 1986 ; Vol. 27, No. 1. pp. 35-42.
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