Systemic focal epileptogenesis

M. P. Remler, W. H. Marcussen

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Rats that receive radiation to 0.25 cc of one cerebral hemisphere are clinically and electroencephalographically normal until there is a breakdown of the blood-brain barrier (BBB) at 3 to 6 months postradiation. This BBB lesion can be detected by transient focal seizure activity produced by the BBB-excluded systemic convulsant bicuculline methiodide. In two rats the seizure activity induced by this one injection was self-sustaining. In seven of 15 other rats tested, the subsequent administration of repeated 2 mg/kg injections created a chronic focus that continued to spike with great frequency for 3 weeks or more without further administration of any convulsant. In three of eight other rats, implanted minipumps delivering 180 μg/h of bicuculline methiodide produced self-sustaining epileptic activity.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
Issue number1
StatePublished - 1986

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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