Systemic distribution of blood flow during T-2 toxin induced shock in swine

Gregg R. Lundeen, Robert H Poppenga, Val R. Beasley, William B. Buck, William J. Transquilli, Richard J. Lambert

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Three groups of swine (6 per group) were used to determine hemodynamic and blood flow alterations induced by T-2 toxin. Two groups were dosed at 0.6 or 2.4 mg/kg T-2 toxin, and one group served as a vehicle control (70% ethanol). Organ blood flow was determined at 0 hr (predosing) and at 90-min intervals for 6 hr postdosing using 15-μm diameter radionuclide labeled microspheres injected into the left atrium. Hemodynamic parameters were obtained at the same time points. The infusion of T-2 toxin resulted in reductions in cardiac output. This trend appeared to reverse itself in the low dose animals after 3 hr, whereas in the high dose group, cardiac output continued to decline. Mean aortic pressure (MAP) declined in a dose dependent fashion which tended to parallel the reduction observed in cardiac output. Heart rate was increased in both groups treated with T-2 toxin. Blood flow to the brain, heart, and kidneys decreased following exposure to the toxin. The relative percentage of cardiac output received by these organs, however, was maintained despite the drop in blood flow. Pancreatic and splenic blood flows were the most severely compromised as a result of T-2 toxicosis. Consequently, the percentage of cardiac output going to the pancreas and spleen was dramatically reduced. Adrenal, hepatic, and total gastrointestinal blood flows increased or did not change from control values. As a result, the percentage of cardiac output supplying these organs increased.

Original languageEnglish (US)
Pages (from-to)309-323
Number of pages15
JournalFundamental and Applied Toxicology
Volume7
Issue number2
DOIs
StatePublished - 1986
Externally publishedYes

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T-2 Toxin
Cardiac Output
Shock
Blood
Swine
Hemodynamics
Heart Atria
Microspheres
Radioisotopes
Pancreas
Brain
Arterial Pressure
Animals
Ethanol
Spleen
Heart Rate
Kidney
Liver

ASJC Scopus subject areas

  • Toxicology

Cite this

Systemic distribution of blood flow during T-2 toxin induced shock in swine. / Lundeen, Gregg R.; Poppenga, Robert H; Beasley, Val R.; Buck, William B.; Transquilli, William J.; Lambert, Richard J.

In: Fundamental and Applied Toxicology, Vol. 7, No. 2, 1986, p. 309-323.

Research output: Contribution to journalArticle

Lundeen, Gregg R. ; Poppenga, Robert H ; Beasley, Val R. ; Buck, William B. ; Transquilli, William J. ; Lambert, Richard J. / Systemic distribution of blood flow during T-2 toxin induced shock in swine. In: Fundamental and Applied Toxicology. 1986 ; Vol. 7, No. 2. pp. 309-323.
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