Systemic and pulmonary haemodynamics in normal neonatal foals.

W. P. Thomas, John E Madigan, K. Q. Backus, W. E. Powell

Research output: Contribution to journalArticle

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Abstract

Cardiopulmonary function was studied in 10 full-term healthy foals from birth to 14 days of age. Systemic and pulmonary haemodynamics were recorded in lateral recumbency via indwelling aortic and pulmonary artery catheters. Mean body weight increased from 45.4 +/- 2.4 kg on Day 1 to 70.6 +/- 6.1 kg on Day 14. All foals had a continuous murmur of patent ductus arteriosus for 3-6 days. From Day 1 (12 h old) to Day 14, heart rate increased (89 +/- 4 to 95 +/- 5/min), mean aortic pressure increased (87.7 +/- 1.9 to 100.3 +/- 3.2 mmHg), mean pulmonary artery pressure decreased (38.6 +/- 4.6 to 27.4 +/- 3.0 mmHg), mean right atrial pressure was unchanged (4.5 +/- 0.5 to 4.6 +/- 0.9 mmHg), mean pulmonary artery wedge pressure was unchanged (7.6 +/- 0.9 mmHg to 8.1 +/- 0.7 mmHg), cardiac output increased (8.03 +/- 0.59 to 15.88 +/- 1.90 l/min), cardiac index increased (180.5 +/- 10.3 to 222.1 +/- 21.6 ml/kg/min), stroke volume increased (90.4 +/- 5.7 to 164.2 +/- 25.9 ml), stroke volume index was unchanged (2.04 +/- 0.10 to 2.30 +/- 0.35 ml/kg), pulmonary vascular resistance decreased (314 +/- 39 to 104 +/- 21 aru), systemic vascular resistance decreased (858 +/- 70 to 497 +/- 87 aru), and pulmonary/systemic resistance ratio decreased (38 +/- 6 to 21 +/- 5%). All changes were gradual, although pulmonary artery pressure and pulmonary vascular resistance decreased rapidly in the first 24 h. Catheters were well tolerated over several days, indicating their feasibility for studying cardiovascular function in full-term or premature equine neonates.

Original languageEnglish (US)
Pages (from-to)623-628
Number of pages6
JournalJournal of reproduction and fertility. Supplement
Volume35
StatePublished - 1987

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Vascular Resistance
Pulmonary Artery
Hemodynamics
Stroke Volume
Lung
Catheters
Pressure
Pulmonary Wedge Pressure
Patent Ductus Arteriosus
Atrial Pressure
Cardiac Output
Horses
Arterial Pressure
Heart Rate
Body Weight
Parturition

ASJC Scopus subject areas

  • Medicine(all)

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Systemic and pulmonary haemodynamics in normal neonatal foals. / Thomas, W. P.; Madigan, John E; Backus, K. Q.; Powell, W. E.

In: Journal of reproduction and fertility. Supplement, Vol. 35, 1987, p. 623-628.

Research output: Contribution to journalArticle

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