TY - JOUR
T1 - Systemic analyses of immunophenotypes of peripheral T cells in non-segmental vitiligo
T2 - Implication of defective natural killer T cells
AU - Zhou, Li
AU - Li, Kai
AU - Shi, Yu Ling
AU - Hamzavi, Iltefat
AU - Gao, Tian Wen
AU - Henderson, Marsha
AU - Huggins, Richard H.
AU - Agbai, Oma
AU - Mahmoud, Bassel
AU - Mi, Xiaofan
AU - Lim, Henry W.
AU - Mi, Qing Sheng
PY - 2012/9
Y1 - 2012/9
N2 - Although it is widely believed that non-segmental vitiligo (NSV) results from the autoimmune destruction of melanocytes, a clear understanding of defects in immune tolerance, which mediate this uncontrolled self-reactivity, is still lacking. In the present study, we systemically evaluated circulating regulatory T (Treg) cells, including CD4+CD25+FoxP3+ Treg cells and invariant natural killer T (iNKT) cells, as well as naïve and memory CD4+ and CD8+ T cells and their cytokine production, in a cohort of 43 progressive NSV patients with race-, gender-, and age-matched healthy controls. We found that the general immunophenotypes of CD4+ and CD8+ T cells and the percentage of CD4+CD25+FoxP3+ Tregs were comparable between NSV and healthy controls. However, percentages of peripheral iNKT cells were significantly decreased in NSV patients compared to that in healthy controls. Our data confirm the previous notion that the percentage of peripheral CD4+CD25+FoxP3+ Tregs remains unaltered in NSV and suggests the involvement of defective iNKT cells in the pathogenesis of NSV.
AB - Although it is widely believed that non-segmental vitiligo (NSV) results from the autoimmune destruction of melanocytes, a clear understanding of defects in immune tolerance, which mediate this uncontrolled self-reactivity, is still lacking. In the present study, we systemically evaluated circulating regulatory T (Treg) cells, including CD4+CD25+FoxP3+ Treg cells and invariant natural killer T (iNKT) cells, as well as naïve and memory CD4+ and CD8+ T cells and their cytokine production, in a cohort of 43 progressive NSV patients with race-, gender-, and age-matched healthy controls. We found that the general immunophenotypes of CD4+ and CD8+ T cells and the percentage of CD4+CD25+FoxP3+ Tregs were comparable between NSV and healthy controls. However, percentages of peripheral iNKT cells were significantly decreased in NSV patients compared to that in healthy controls. Our data confirm the previous notion that the percentage of peripheral CD4+CD25+FoxP3+ Tregs remains unaltered in NSV and suggests the involvement of defective iNKT cells in the pathogenesis of NSV.
KW - Immunophenotypes
KW - Invariant natural killer T cells
KW - Non-segmental vitiligo
KW - Regulatory T cells
UR - http://www.scopus.com/inward/record.url?scp=84865570637&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865570637&partnerID=8YFLogxK
U2 - 10.1111/j.1755-148X.2012.01019.x
DO - 10.1111/j.1755-148X.2012.01019.x
M3 - Article
C2 - 22591262
AN - SCOPUS:84865570637
VL - 25
SP - 602
EP - 611
JO - Pigment Cell and Melanoma Research
JF - Pigment Cell and Melanoma Research
SN - 1755-1471
IS - 5
ER -