Systemic analyses of immunophenotypes of peripheral T cells in non-segmental vitiligo: Implication of defective natural killer T cells

Li Zhou, Kai Li, Yu Ling Shi, Iltefat Hamzavi, Tian Wen Gao, Marsha Henderson, Richard H. Huggins, Oma Agbai, Bassel Mahmoud, Xiaofan Mi, Henry W. Lim, Qing Sheng Mi

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Although it is widely believed that non-segmental vitiligo (NSV) results from the autoimmune destruction of melanocytes, a clear understanding of defects in immune tolerance, which mediate this uncontrolled self-reactivity, is still lacking. In the present study, we systemically evaluated circulating regulatory T (Treg) cells, including CD4+CD25+FoxP3+ Treg cells and invariant natural killer T (iNKT) cells, as well as naïve and memory CD4+ and CD8+ T cells and their cytokine production, in a cohort of 43 progressive NSV patients with race-, gender-, and age-matched healthy controls. We found that the general immunophenotypes of CD4+ and CD8+ T cells and the percentage of CD4+CD25+FoxP3+ Tregs were comparable between NSV and healthy controls. However, percentages of peripheral iNKT cells were significantly decreased in NSV patients compared to that in healthy controls. Our data confirm the previous notion that the percentage of peripheral CD4+CD25+FoxP3+ Tregs remains unaltered in NSV and suggests the involvement of defective iNKT cells in the pathogenesis of NSV.

Original languageEnglish (US)
Pages (from-to)602-611
Number of pages10
JournalPigment Cell and Melanoma Research
Volume25
Issue number5
DOIs
StatePublished - Sep 2012
Externally publishedYes

Keywords

  • Immunophenotypes
  • Invariant natural killer T cells
  • Non-segmental vitiligo
  • Regulatory T cells

ASJC Scopus subject areas

  • Dermatology
  • Oncology
  • Biochemistry, Genetics and Molecular Biology(all)

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    Zhou, L., Li, K., Shi, Y. L., Hamzavi, I., Gao, T. W., Henderson, M., Huggins, R. H., Agbai, O., Mahmoud, B., Mi, X., Lim, H. W., & Mi, Q. S. (2012). Systemic analyses of immunophenotypes of peripheral T cells in non-segmental vitiligo: Implication of defective natural killer T cells. Pigment Cell and Melanoma Research, 25(5), 602-611. https://doi.org/10.1111/j.1755-148X.2012.01019.x