Systemic absorption of epinephrine after endoscopic submucosal injection in patients with bleeding peptic ulcers

J. Y. Sung; S. C S Chung; J. M. Low; R. Cocks; S. M. Ip; P. Tan; J. W C Leung; T. E. Oh; A. K C Li

Systemic absorption of epinephrine after endoscopic submucosal injection in patients with bleeding peptic ulcers

J. Y. Sung, S. C S Chung, J. M. Low, R. Cocks, S. M. Ip, P. Tan, J. W C Leung, T. E. Oh, A. K C Li

Research output: Contribution to journal › Article › peer-review

Abstract

Epinephrine injection is an effective, simple, and economical method of endoscopic hemostasis for bleeding peptic ulcers. We measured catecholamine levels in 18 patients with actively bleeding ulcers (8 gastric ulcers and 10 duodenal ulcers) treated by endoscopic injection. Injection of epinephrine (1:10,000 IU) was given until bleeding from the ulcers stopped. Catecholamine levels were assayed by high-pressure liquid chromatography. Immediately after the injection the plasma level of epinephrine rose by four to five times above the basal level and returned to the baseline in 20 minutes. Norepinephrine levels were not significantly raised in these patients. No cardiovascular complications were seen. Although adverse cardiac events have not been recorded, it seems prudent to monitor these patients closely during and immediately after epinephrine injection.

Original language	English (US)
Pages (from-to)	20-22
Number of pages	3
Journal	Gastrointestinal Endoscopy
Volume	39
Issue number	1
State	Published - 1993
Externally published	Yes

ASJC Scopus subject areas

Gastroenterology

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title = "Systemic absorption of epinephrine after endoscopic submucosal injection in patients with bleeding peptic ulcers",

abstract = "Epinephrine injection is an effective, simple, and economical method of endoscopic hemostasis for bleeding peptic ulcers. We measured catecholamine levels in 18 patients with actively bleeding ulcers (8 gastric ulcers and 10 duodenal ulcers) treated by endoscopic injection. Injection of epinephrine (1:10,000 IU) was given until bleeding from the ulcers stopped. Catecholamine levels were assayed by high-pressure liquid chromatography. Immediately after the injection the plasma level of epinephrine rose by four to five times above the basal level and returned to the baseline in 20 minutes. Norepinephrine levels were not significantly raised in these patients. No cardiovascular complications were seen. Although adverse cardiac events have not been recorded, it seems prudent to monitor these patients closely during and immediately after epinephrine injection.",

author = "Sung, {J. Y.} and Chung, {S. C S} and Low, {J. M.} and R. Cocks and Ip, {S. M.} and P. Tan and Leung, {J. W C} and Oh, {T. E.} and Li, {A. K C}",

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T1 - Systemic absorption of epinephrine after endoscopic submucosal injection in patients with bleeding peptic ulcers

AU - Sung, J. Y.

AU - Chung, S. C S

AU - Low, J. M.

AU - Cocks, R.

AU - Ip, S. M.

AU - Tan, P.

AU - Leung, J. W C

AU - Oh, T. E.

AU - Li, A. K C

PY - 1993

Y1 - 1993

N2 - Epinephrine injection is an effective, simple, and economical method of endoscopic hemostasis for bleeding peptic ulcers. We measured catecholamine levels in 18 patients with actively bleeding ulcers (8 gastric ulcers and 10 duodenal ulcers) treated by endoscopic injection. Injection of epinephrine (1:10,000 IU) was given until bleeding from the ulcers stopped. Catecholamine levels were assayed by high-pressure liquid chromatography. Immediately after the injection the plasma level of epinephrine rose by four to five times above the basal level and returned to the baseline in 20 minutes. Norepinephrine levels were not significantly raised in these patients. No cardiovascular complications were seen. Although adverse cardiac events have not been recorded, it seems prudent to monitor these patients closely during and immediately after epinephrine injection.

AB - Epinephrine injection is an effective, simple, and economical method of endoscopic hemostasis for bleeding peptic ulcers. We measured catecholamine levels in 18 patients with actively bleeding ulcers (8 gastric ulcers and 10 duodenal ulcers) treated by endoscopic injection. Injection of epinephrine (1:10,000 IU) was given until bleeding from the ulcers stopped. Catecholamine levels were assayed by high-pressure liquid chromatography. Immediately after the injection the plasma level of epinephrine rose by four to five times above the basal level and returned to the baseline in 20 minutes. Norepinephrine levels were not significantly raised in these patients. No cardiovascular complications were seen. Although adverse cardiac events have not been recorded, it seems prudent to monitor these patients closely during and immediately after epinephrine injection.

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Systemic absorption of epinephrine after endoscopic submucosal injection in patients with bleeding peptic ulcers

Abstract

ASJC Scopus subject areas

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