Abstract
Epinephrine injection is an effective, simple, and economical method of endoscopic hemostasis for bleeding peptic ulcers. We measured catecholamine levels in 18 patients with actively bleeding ulcers (8 gastric ulcers and 10 duodenal ulcers) treated by endoscopic injection. Injection of epinephrine (1:10,000 IU) was given until bleeding from the ulcers stopped. Catecholamine levels were assayed by high-pressure liquid chromatography. Immediately after the injection the plasma level of epinephrine rose by four to five times above the basal level and returned to the baseline in 20 minutes. Norepinephrine levels were not significantly raised in these patients. No cardiovascular complications were seen. Although adverse cardiac events have not been recorded, it seems prudent to monitor these patients closely during and immediately after epinephrine injection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 20-22 |
| Number of pages | 3 |
| Journal | Gastrointestinal Endoscopy |
| Volume | 39 |
| Issue number | 1 |
| State | Published - 1993 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Gastroenterology
Cite this
Systemic absorption of epinephrine after endoscopic submucosal injection in patients with bleeding peptic ulcers. / Sung, J. Y.; Chung, S. C S; Low, J. M.; Cocks, R.; Ip, S. M.; Leung, Joseph; Leung, J. W C; Oh, T. E.; Li, A. K C.
In: Gastrointestinal Endoscopy, Vol. 39, No. 1, 1993, p. 20-22.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Systemic absorption of epinephrine after endoscopic submucosal injection in patients with bleeding peptic ulcers
AU - Sung, J. Y.
AU - Chung, S. C S
AU - Low, J. M.
AU - Cocks, R.
AU - Ip, S. M.
AU - Leung, Joseph
AU - Leung, J. W C
AU - Oh, T. E.
AU - Li, A. K C
PY - 1993
Y1 - 1993
N2 - Epinephrine injection is an effective, simple, and economical method of endoscopic hemostasis for bleeding peptic ulcers. We measured catecholamine levels in 18 patients with actively bleeding ulcers (8 gastric ulcers and 10 duodenal ulcers) treated by endoscopic injection. Injection of epinephrine (1:10,000 IU) was given until bleeding from the ulcers stopped. Catecholamine levels were assayed by high-pressure liquid chromatography. Immediately after the injection the plasma level of epinephrine rose by four to five times above the basal level and returned to the baseline in 20 minutes. Norepinephrine levels were not significantly raised in these patients. No cardiovascular complications were seen. Although adverse cardiac events have not been recorded, it seems prudent to monitor these patients closely during and immediately after epinephrine injection.
AB - Epinephrine injection is an effective, simple, and economical method of endoscopic hemostasis for bleeding peptic ulcers. We measured catecholamine levels in 18 patients with actively bleeding ulcers (8 gastric ulcers and 10 duodenal ulcers) treated by endoscopic injection. Injection of epinephrine (1:10,000 IU) was given until bleeding from the ulcers stopped. Catecholamine levels were assayed by high-pressure liquid chromatography. Immediately after the injection the plasma level of epinephrine rose by four to five times above the basal level and returned to the baseline in 20 minutes. Norepinephrine levels were not significantly raised in these patients. No cardiovascular complications were seen. Although adverse cardiac events have not been recorded, it seems prudent to monitor these patients closely during and immediately after epinephrine injection.
UR - http://www.scopus.com/inward/record.url?scp=0027532460&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027532460&partnerID=8YFLogxK
M3 - Article
VL - 39
SP - 20
EP - 22
JO - Gastrointestinal Endoscopy
JF - Gastrointestinal Endoscopy
SN - 0016-5107
IS - 1
ER -