Systematic chemoenzymatic synthesis of O-sulfated sialyl Lewis x antigens

Abhishek Santra, Hai Yu, Nova Tasnima, Musleh M. Muthana, Yanhong Li, Jie Zeng, Nicholas Kenyon, Angelique Y. Louie, Xi Chen

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

O-Sulfated sialyl Lewis x antigens play important roles in nature. However, due to their structural complexity, they are not readily accessible by either chemical or enzymatic synthetic processes. Taking advantage of a bacterial sialyltransferase mutant that can catalyze the transfer of different sialic acid forms from the corresponding sugar nucleotide donors to Lewis x antigens, which are fucosylated glycans, as well as an efficient one-pot multienzyme (OPME) sialylation system, O-sulfated sialyl Lewis x antigens containing different sialic acid forms and O-sulfation at different locations were systematically synthesized by chemoenzymatic methods.

Original languageEnglish (US)
Pages (from-to)2827-2831
Number of pages5
JournalChemical Science
Volume7
Issue number4
DOIs
StatePublished - Apr 1 2016

ASJC Scopus subject areas

  • Chemistry(all)

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    Santra, A., Yu, H., Tasnima, N., Muthana, M. M., Li, Y., Zeng, J., Kenyon, N., Louie, A. Y., & Chen, X. (2016). Systematic chemoenzymatic synthesis of O-sulfated sialyl Lewis x antigens. Chemical Science, 7(4), 2827-2831. https://doi.org/10.1039/c5sc04104j