SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans

Sarit Smolikov, Andreas Eizinger, Kristina Schild-Prufert, Allison Hurlburt, Kent McDonald, JoAnne Engebrecht, Anne M. Villeneuve, Mónica P. Colaiácovo

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Synaptonemal complex (SC) formation must be regulated to occur only between aligned pairs of homologous chromosomes, ultimately ensuring proper chromosome segregation in meiosis. Here we identify SYP-3, a coiled-coil protein that is required for assembly of the central region of the SC and for restricting its loading to occur only in an appropriate context, forming structures that bridge the axes of paired meiotic chromosomes in Caenorhabditis elegans. We find that inappropriate loading of central region proteins interferes with homolog pairing, likely by triggering a premature change in chromosome configuration during early prophase that terminates the search for homologs. As a result, syp-3 mutants lack chiasmata and exhibit increased chromosome missegregation. Altogether, our studies lead us to propose that SYP-3 regulates synapsis along chromosomes, contributing to meiotic progression in early prophase.

Original languageEnglish (US)
Pages (from-to)2015-2025
Number of pages11
JournalGenetics
Volume176
Issue number4
DOIs
StatePublished - Aug 2007

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Synaptonemal Complex
Caenorhabditis elegans
Meiosis
Chromosomes
Prophase
Chromosome Pairing
Chromosome Segregation
Proteins

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Smolikov, S., Eizinger, A., Schild-Prufert, K., Hurlburt, A., McDonald, K., Engebrecht, J., ... Colaiácovo, M. P. (2007). SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans. Genetics, 176(4), 2015-2025. https://doi.org/10.1534/genetics.107.072413

SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans. / Smolikov, Sarit; Eizinger, Andreas; Schild-Prufert, Kristina; Hurlburt, Allison; McDonald, Kent; Engebrecht, JoAnne; Villeneuve, Anne M.; Colaiácovo, Mónica P.

In: Genetics, Vol. 176, No. 4, 08.2007, p. 2015-2025.

Research output: Contribution to journalArticle

Smolikov, S, Eizinger, A, Schild-Prufert, K, Hurlburt, A, McDonald, K, Engebrecht, J, Villeneuve, AM & Colaiácovo, MP 2007, 'SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans', Genetics, vol. 176, no. 4, pp. 2015-2025. https://doi.org/10.1534/genetics.107.072413
Smolikov S, Eizinger A, Schild-Prufert K, Hurlburt A, McDonald K, Engebrecht J et al. SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans. Genetics. 2007 Aug;176(4):2015-2025. https://doi.org/10.1534/genetics.107.072413
Smolikov, Sarit ; Eizinger, Andreas ; Schild-Prufert, Kristina ; Hurlburt, Allison ; McDonald, Kent ; Engebrecht, JoAnne ; Villeneuve, Anne M. ; Colaiácovo, Mónica P. / SYP-3 restricts synaptonemal complex assembly to bridge paired chromosome axes during meiosis in Caenorhabditis elegans. In: Genetics. 2007 ; Vol. 176, No. 4. pp. 2015-2025.
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