Synthetic mammalian riboswitches based on guanine aptazyme

Yoko Nomura, Deepak Kumar, Yohei Yokobayashi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Allosteric hammerhead ribozymes (aptazymes) that are activated by guanine were used to control mammalian gene expression in cis and in trans. Coexpression of the two mechanistically distinct riboswitches resulted in an improved dynamic range of gene expression.

Original languageEnglish (US)
Pages (from-to)7215-7217
Number of pages3
JournalChemical Communications
Volume48
Issue number57
DOIs
StatePublished - Jul 21 2012

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Riboswitch
Guanine
Gene expression

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Synthetic mammalian riboswitches based on guanine aptazyme. / Nomura, Yoko; Kumar, Deepak; Yokobayashi, Yohei.

In: Chemical Communications, Vol. 48, No. 57, 21.07.2012, p. 7215-7217.

Research output: Contribution to journalArticle

Nomura, Y, Kumar, D & Yokobayashi, Y 2012, 'Synthetic mammalian riboswitches based on guanine aptazyme', Chemical Communications, vol. 48, no. 57, pp. 7215-7217. https://doi.org/10.1039/c2cc33140c
Nomura, Yoko ; Kumar, Deepak ; Yokobayashi, Yohei. / Synthetic mammalian riboswitches based on guanine aptazyme. In: Chemical Communications. 2012 ; Vol. 48, No. 57. pp. 7215-7217.
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