Synthetic mammalian riboswitches based on guanine aptazyme

Yoko Nomura, Deepak Kumar, Yohei Yokobayashi

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Allosteric hammerhead ribozymes (aptazymes) that are activated by guanine were used to control mammalian gene expression in cis and in trans. Coexpression of the two mechanistically distinct riboswitches resulted in an improved dynamic range of gene expression.

Original languageEnglish (US)
Pages (from-to)7215-7217
Number of pages3
JournalChemical Communications
Issue number57
StatePublished - Jul 21 2012

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)


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