Abstract
The need for replacement tissues or organs requires a tissue supply that cannot be satisfied by the donor supply. The tissue engineering and regeneration field is focused on the development of biological tissue and organ substitutes and may provide functional tissues to restore, maintain, or improve tissue formation. This field is already providing new therapeutic options to bypass the limitations of organ{plus 45 degree rule}tissue transplantation and will likely increase in medical importance in the future. This interdisciplinary field accommodates principles of life sciences and engineering and encompasses three major strategies. The first, guided tissue regeneration, relies on synthetic matrices that are conductive to host cells populating a tissue defect site and reforming the lost tissue. The second approach, inductive strategy, involves the delivery of growth factors, typically using drug delivery strategies, which are targeted to specific cell populations in the tissues surrounding the tissue defect. In the third approach, specific cell populations, typically multiplied in culture, are directly delivered to the site at which one desires to create a new tissue or organ. In all of these approaches, the knowledge acquired from developmental studies often serves as a template for the tissue engineering approach for a specific tissue or organ. This article overviews the development of synthetic extracellular matrices (ECMs) for use in tissue engineering that aim to mimic functions of the native ECM of developing and regenerating tissues. In addition to the potential therapeutic uses of these materials, they also provide model systems for basic studies that may shed light on developmental processes.
| Original language | English (US) |
|---|---|
| Title of host publication | Current Topics in Developmental Biology |
| Pages | 181-205 |
| Number of pages | 25 |
| DOIs | |
| State | Published - Dec 1 2004 |
| Externally published | Yes |
Publication series
| Name | Current Topics in Developmental Biology |
|---|---|
| Volume | 64 |
| ISSN (Print) | 0070-2153 |
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ASJC Scopus subject areas
- Developmental Biology
Cite this
Synthetic Extracellular Matrices for Tissue Engineering and Regeneration. / Silva, Eduardo; Mooney, David J.
Current Topics in Developmental Biology. 2004. p. 181-205 (Current Topics in Developmental Biology; Vol. 64).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Synthetic Extracellular Matrices for Tissue Engineering and Regeneration
AU - Silva, Eduardo
AU - Mooney, David J.
PY - 2004/12/1
Y1 - 2004/12/1
N2 - The need for replacement tissues or organs requires a tissue supply that cannot be satisfied by the donor supply. The tissue engineering and regeneration field is focused on the development of biological tissue and organ substitutes and may provide functional tissues to restore, maintain, or improve tissue formation. This field is already providing new therapeutic options to bypass the limitations of organ{plus 45 degree rule}tissue transplantation and will likely increase in medical importance in the future. This interdisciplinary field accommodates principles of life sciences and engineering and encompasses three major strategies. The first, guided tissue regeneration, relies on synthetic matrices that are conductive to host cells populating a tissue defect site and reforming the lost tissue. The second approach, inductive strategy, involves the delivery of growth factors, typically using drug delivery strategies, which are targeted to specific cell populations in the tissues surrounding the tissue defect. In the third approach, specific cell populations, typically multiplied in culture, are directly delivered to the site at which one desires to create a new tissue or organ. In all of these approaches, the knowledge acquired from developmental studies often serves as a template for the tissue engineering approach for a specific tissue or organ. This article overviews the development of synthetic extracellular matrices (ECMs) for use in tissue engineering that aim to mimic functions of the native ECM of developing and regenerating tissues. In addition to the potential therapeutic uses of these materials, they also provide model systems for basic studies that may shed light on developmental processes.
AB - The need for replacement tissues or organs requires a tissue supply that cannot be satisfied by the donor supply. The tissue engineering and regeneration field is focused on the development of biological tissue and organ substitutes and may provide functional tissues to restore, maintain, or improve tissue formation. This field is already providing new therapeutic options to bypass the limitations of organ{plus 45 degree rule}tissue transplantation and will likely increase in medical importance in the future. This interdisciplinary field accommodates principles of life sciences and engineering and encompasses three major strategies. The first, guided tissue regeneration, relies on synthetic matrices that are conductive to host cells populating a tissue defect site and reforming the lost tissue. The second approach, inductive strategy, involves the delivery of growth factors, typically using drug delivery strategies, which are targeted to specific cell populations in the tissues surrounding the tissue defect. In the third approach, specific cell populations, typically multiplied in culture, are directly delivered to the site at which one desires to create a new tissue or organ. In all of these approaches, the knowledge acquired from developmental studies often serves as a template for the tissue engineering approach for a specific tissue or organ. This article overviews the development of synthetic extracellular matrices (ECMs) for use in tissue engineering that aim to mimic functions of the native ECM of developing and regenerating tissues. In addition to the potential therapeutic uses of these materials, they also provide model systems for basic studies that may shed light on developmental processes.
UR - http://www.scopus.com/inward/record.url?scp=16644370406&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=16644370406&partnerID=8YFLogxK
U2 - 10.1016/S0070-2153(04)64008-7
DO - 10.1016/S0070-2153(04)64008-7
M3 - Chapter
C2 - 15563948
AN - SCOPUS:16644370406
SN - 0121531643
SN - 9780121531645
T3 - Current Topics in Developmental Biology
SP - 181
EP - 205
BT - Current Topics in Developmental Biology
ER -