Synthetic disialyl hexasaccharides protect neonatal rats from necrotizing enterocolitis

Hai Yu, Kam Lau, Vireak Thon, Chloe A. Autran, Evelyn Jantscher-Krenn, Mengyang Xue, Yanhong Li, Go Sugiarto, Jingyao Qu, Shengmao Mu, Li Ding, Lars Bode, Xi Chen

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

Two novel synthetic α2-6-linked disialyl hexasaccharides, disialyllacto-N-neotetraose (DSLNnT) and α2-6-linked disialyllacto-N- tetraose (DS′LNT), were readily obtained by highly efficient one-pot multienzyme (OPME) reactions. The sequential OPME systems described herein allowed the use of an inexpensive disaccharide and simple monosaccharides to synthesize the desired complex oligosaccharides with high efficiency and selectivity. DSLNnT and DS′LNT were shown to protect neonatal rats from necrotizing enterocolitis (NEC) and are good therapeutic candidates for preclinical experiments and clinical application in treating NEC in preterm infants. Sweet protection: Two novel synthetic disialyl hexaoses obtained by highly efficient one-pot multienzyme (OPME) reactions were shown to protect neonatal rats from necrotizing enterocolitis (see scheme; GlcNAC: N-acetylglucosamine; Gal: galactose; Neu5Ac: N-acetylneuraminic acid; DSLNnT: disialyllacto-N-neotetraose; LNT: lacto-N-tetraose; DS'LNT: α2 - 6-linked disialyllacto-N-tetraose).

Original languageEnglish (US)
Pages (from-to)6687-6691
Number of pages5
JournalAngewandte Chemie - International Edition
Volume53
Issue number26
DOIs
StatePublished - Jun 23 2014

Keywords

  • disialyl glycans
  • enzymatic synthesis
  • enzymes
  • necrotizing enterocolitis
  • oligosaccharides

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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