Synthesis of (-)-viriditoxin: A 6,6′-binaphthopyran-2-one that targets the bacterial cell division protein FtsZ

Young Sam Park, Charles I. Grove, Marcos González-López, Sameer Urgaonkar, James C. Fettinger, Jared T. Shaw

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

(Chemical Equation Presented) Remote control: Vanadium catalysts provide the key to synthesizing the bacteria-fighting natural product viriditoxin. An achiral catalyst shows modest levels of remote diastereocontrol induced by the lactone stereogenic center and chiral catalysts can be used to enhance or reverse this inherent selectivity.

Original languageEnglish (US)
Pages (from-to)3730-3733
Number of pages4
JournalAngewandte Chemie - International Edition
Volume50
Issue number16
DOIs
StatePublished - Apr 11 2011

Keywords

  • Biaryls
  • Enantioselective catalysis
  • Natural product synthesis
  • Vanadium catalysis
  • Viriditoxin

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

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