Abstract
(Chemical Equation Presented) Remote control: Vanadium catalysts provide the key to synthesizing the bacteria-fighting natural product viriditoxin. An achiral catalyst shows modest levels of remote diastereocontrol induced by the lactone stereogenic center and chiral catalysts can be used to enhance or reverse this inherent selectivity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 3730-3733 |
| Number of pages | 4 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 50 |
| Issue number | 16 |
| DOIs | |
| State | Published - Apr 11 2011 |
Keywords
- Biaryls
- Enantioselective catalysis
- Natural product synthesis
- Vanadium catalysis
- Viriditoxin
ASJC Scopus subject areas
- Chemistry(all)
- Catalysis
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Park, Y. S., Grove, C. I., González-López, M., Urgaonkar, S., Fettinger, J. C., & Shaw, J. T. (2011). Synthesis of (-)-viriditoxin: A 6,6′-binaphthopyran-2-one that targets the bacterial cell division protein FtsZ. Angewandte Chemie - International Edition, 50(16), 3730-3733. https://doi.org/10.1002/anie.201007298