Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles

M. H. El-Badri; Mark J. Kurth

doi:10.1021/cc800141s

Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles

M. H. El-Badri, Mark J. Kurth

Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The first examples of thiazolo[4,5-e]benzoisoxazoles are obtained from bromination of dihydrobenzo[d]isoxazol-4(5H)-one followed by cyclocondensation with thiourea, in the presence of DDQ. Analogously, cyclocondensation with thioamides provided 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles. A 55-member library of these heterocycles is reported.

Original language	English (US)
Pages (from-to)	228-238
Number of pages	11
Journal	Journal of Combinatorial Chemistry
Volume	11
Issue number	2
DOIs	https://doi.org/10.1021/cc800141s
State	Published - Mar 9 2009

ASJC Scopus subject areas

Chemistry(all)
Medicine(all)

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Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles

Abstract

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