Abstract
The first examples of thiazolo[4,5-e]benzoisoxazoles are obtained from bromination of dihydrobenzo[d]isoxazol-4(5H)-one followed by cyclocondensation with thiourea, in the presence of DDQ. Analogously, cyclocondensation with thioamides provided 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles. A 55-member library of these heterocycles is reported.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 228-238 |
| Number of pages | 11 |
| Journal | Journal of Combinatorial Chemistry |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 9 2009 |
ASJC Scopus subject areas
- Chemistry(all)
- Medicine(all)
Fingerprint Dive into the research topics of 'Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles'. Together they form a unique fingerprint.
Cite this
El-Badri, M. H., & Kurth, M. J. (2009). Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles. Journal of Combinatorial Chemistry, 11(2), 228-238. https://doi.org/10.1021/cc800141s