Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles

M. H. El-Badri, Mark J. Kurth

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The first examples of thiazolo[4,5-e]benzoisoxazoles are obtained from bromination of dihydrobenzo[d]isoxazol-4(5H)-one followed by cyclocondensation with thiourea, in the presence of DDQ. Analogously, cyclocondensation with thioamides provided 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles. A 55-member library of these heterocycles is reported.

Original languageEnglish (US)
Pages (from-to)228-238
Number of pages11
JournalJournal of Combinatorial Chemistry
Volume11
Issue number2
DOIs
StatePublished - Mar 9 2009

ASJC Scopus subject areas

  • Chemistry(all)
  • Medicine(all)

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