Abstract
The first examples of thiazolo[4,5-e]benzoisoxazoles are obtained from bromination of dihydrobenzo[d]isoxazol-4(5H)-one followed by cyclocondensation with thiourea, in the presence of DDQ. Analogously, cyclocondensation with thioamides provided 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles. A 55-member library of these heterocycles is reported.
Original language | English (US) |
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Pages (from-to) | 228-238 |
Number of pages | 11 |
Journal | Journal of Combinatorial Chemistry |
Volume | 11 |
Issue number | 2 |
DOIs | |
State | Published - Mar 9 2009 |
ASJC Scopus subject areas
- Chemistry(all)
- Medicine(all)